Should You Worry About LDL Cholesterol? [LDL Cholesterol and Heart Disease]

I talk about Total Cholesterol and LDL Cholesterol and Heart Disease. I give you the facts, provide you with several systematic reviews and meta-analyses on total fat, saturated fat and cholesterol, LDL cholesterol, and the risk of cardiovascular disease.

Should You Really Worry About High LDL Cholesterol Levels? This video will answer this question.

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So, here is my search:

The issue with most of the studies is that they focus on the fact that saturated fat increases LDL cholesterol. And then they automatically assume that it increases cardiovascular disease risk.
It's this unquestionable fact.

That's when we fail. When we stop questioning things.

A good example is this study:
Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2125600/

Conclusion: Saturated fat raises your LDL cholesterol.
-That still doesn’t prove that this LDL increases cardiovascular disease risk.

Then more relevant studies and I found these studies, that actually looked at the risk, not only the increased LDL cholesterol:

So, the first study:
Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
https://pubmed.ncbi.nlm.nih.gov/20071648/

They start by saying that a reduction in dietary saturated fat has generally been thought to improve cardiovascular health.

-Their Conclusions was: A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD.

Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451787/

-Conclusion: no association was observed between total fat, monounsaturated fat, saturated fat, and polyunsaturated fat and risk of CVDs.

Then, next meta-analysis, looking at dietary cholesterol:
Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/26109578/

-Ant their results showed that Dietary cholesterol was not statistically significantly associated with any coronary artery disease or stroke. Dietary cholesterol statistically significantly increased both serum total cholesterol and low-density lipoprotein (LDL) cholesterol and did not increase the risk of coronary artery disease or stroke.

Here's one long trial:
Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial
https://pubmed.ncbi.nlm.nih.gov/16467234/

-No evidence to support the low-fat diet.

What about the low carbohydrate, high fat ketogenic diet, it is high in fat and saturated fat. It must increase the risk of heart disease.

There's this meta-analysis of randomised controlled trials:
Very-low-carbohydrate ketogenic diet vs low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials
https://pubmed.ncbi.nlm.nih.gov/23651522/

-Conclusion: low carbohydrate, high fat ketogenic diet decreases the risk of cardiovascular disease.

Here’s a study called:
Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis
https://openheart.bmj.com/content/2/1/e000196.abstract?sid=7217c2a8-513e-4e7e-837a-fe5389053fde

And this one is about sugar:
Dietary sugars and cardiometabolic risk: systematic review and meta-analyses of randomized controlled trials of the effects on blood pressure and lipids
https://pubmed.ncbi.nlm.nih.gov/24808490/

So I hope you know now, that LDL Cholesterol does not increase your risk for Heart Disease, and what you eat your fat with matters the most.

References
The association between blood glucose and oxidized lipoprotein(a) in healthy young women
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949859/

Saturated Fat: Part of a Healthy Diet
https://pubmed.ncbi.nlm.nih.gov/30084105/#:~:text=Saturated%20fat%20can%20lead%20to,association%20does%20not%20assign%20causation.

#LDL