FEVER - Should you Fight It? (Research in 2021)

One of the first things a parent will do when a child runs a fever is to reach for the fever-reducing medication. But, is fever a bad thing? Should you fight it? Or, should you let it do what your body wants it to do?

Fever, should you treat it, is a subject sure to irritate many a parent and health-care provider. I wish I had included a chapter about it in Lies My Doctor Told Me. Here's what you need to know, with the research listed below.

Research:
Fever Questioned: https://www.ncbi.nlm.nih.gov/pubmed/8698984
Value of Fever: https://evolutionmedicine.files.wordpress.com/2008/09/adaptive-value-of-fever.pdf
Evidence Against fighting Fever: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145646/
CD8 T cells enhanced by fever: https://jlb.onlinelibrary.wiley.com/doi/full/10.1189/jlb.0511229
Treating fever gave worse outcome: https://www.ncbi.nlm.nih.gov/pubmed/16433601
No improvement in outcome treating fever: https://www.ncbi.nlm.nih.gov/pubmed/23102531
Fever is 600,000,000 years old: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786079/
Lowering fever to prevent febrile seizures: https://www.ncbi.nlm.nih.gov/pubmed/19736332
Lowering fever to prevent febrile seizures: https://www.acepnow.com/article/emergency-physicians-try-antipyretic-therapy-prevent-recurrence-febrile-seizures/
Rethinking Fever: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145646/#B16
Evolution of Fever: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181026/
Fever in Adults: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197931/
A20 gene & Fever: https://www.medicalnewstoday.com/articles/321889#The-protein-that-alters-temperature-reactivity
NF, A20 & Fever: https://www.pnas.org/content/pnas/115/22/E5243.full.pdf
Even Reptiles use Fever to fight Infection: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188478/

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Ken D Berry, MD, is a Family Physician with 20 years of clinical practice.
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