Episode 8/13: Nucleotides // A Course on Abiogenesis by Dr. James Tour

In this episode, Dr. James Tour educates on the 3rd class of compounds needed for life: nucleotides, comprised of a sugar (carbohydrate), a nucleobase, and a phosphate. With the reminder how manufacturers extract nucleotides from biological sources and how the oligomer synthesis cycle in solid phase DNA synthesis must use synthetically-prepared protective mechanisms, prebiotic nucleotide synthesis remains a mystery. Furthermore, it is revealed that the problem of sequence specific biological information—a world where order matters—remains unaddressed, with RNA World still looking incredibly unstable and bleak. Finally, with the secret of relay synthesis exposed, origin of life research faces a real challenge in the quest for prebiotic relevance, especially when these syntheses only provide nucleotides in racemic form and gross mixtures of diastereomers on the ribose.

Video Index:
00:00 - Introduction
00:40 - Reasons & Intent of this Abiogenesis Series
02:17 - Nucleosides & Nucleotides
05:49 - Structure and Composition of DNA/RNA
08:58 - What was said about synthesis
11:40 - Solid Phase DNA Synthesis explained
17:19 - Prebiotic Relevance & Invoking Relay Synthesis
26:57 - "small molecules" to RNA - Never Been Shown
29:57 - Random Information vs Life's Functional Information
32:57 - Prebiotic Sequence Selection
35:18 - RNA Self-Replication
38:18 - Time & Molecular Degradation
48:48 - Summary and What's Next

Links in this Series | Addressing Abiogenesis & Common Misconceptions
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Series Trailer: https://youtu.be/N-RvMStTkx4
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0 - Reasons for this Series: https://youtu.be/71dqAFUb-v0
1 - Introduction to Abiogenesis: https://youtu.be/NqoVxwdWWpg
2 - Primordial Soup: https://youtu.be/tNbl-g8QoAg
3 - Hype: https://youtu.be/Q6b76XQQN00
4 - Homochirality: https://youtu.be/tqbpd3CmBgE
5 - Carbohydrates: https://youtu.be/rdqd_EvpsZM
6 - Building Blocks of Building Blocks: https://youtu.be/rdqd_EvpsZM
7 - Peptides: https://youtu.be/0Hv6KjB0j8Y
8 - Nucleotides: https://youtu.be/CYiguQYCSio
9 - Intermediate Summary & a Call to Colleagues: https://youtu.be/ImPxfmKrmoY
10 - Lipids: https://youtu.be/QTQd5Ifqv2g
11 - Chiral-induced Spin Selectivity: https://youtu.be/VKEZSfuMgL0
12.1 - Cell Construction & The Assembly Problem, Part 1: https://youtu.be/IaJo5jWs_6k
12.2 - Cell Construction & The Assembly Problem, Part 2: https://youtu.be/fDayvhch_W4
13 - Summary & Projections: https://youtu.be/71GTCHkId6M

DNA animations by wehi.edu.au:
https://youtu.be/7Hk9jct2ozY
Transcription - Central Dogma Part 1 by wehi.edu.au:
https://youtu.be/DA2t5N72mgw
Translation - Central Dogma Part 2 by wehi.edu.au:
https://youtu.be/WkI_Vbwn14g

Link to the cited video ("Elucidating the Agenda of James Tour: A Defense of Abiogenesis") can be found in the video description of Episode 0 - "Reasons for this Series" here: https://youtu.be/71dqAFUb-v0

The passionate thumbnail for this video uses a still frame image taken from Dr. Tour's video on Flash Graphene when he says "any" in the phrase "any carbon source" at 0:12: https://youtu.be/hhN5I_ocLSU

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God bless you.

#Abiogenesis #JamesTour #OriginOfLife

~
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