Episode 7/13: Peptides // A Course on Abiogenesis by Dr. James Tour

In this episode, Dr. James Tour teaches the 2nd class of compounds needed for life: peptides. He identifies gross speculatory claims by others, referring to published literature that confirms the implausibility of the sudden emergence of peptides from amino acids. Dr. Tour also walks the viewer through synthesis, showing that without careful activation, side chain protection, and water-free conditions, amino acids do not polymerize into peptides. He then dispels the view that human-made synthesizers, which were not present on prebiotic earth, somehow render polypeptide synthesis as trivial, let alone the fact that amino acids themselves have never been prepared in homochiral fashion using a prebiotically relevant route. Finally, with no solution to the amino acid sequence that comprises functional proteins, Dr. Tour then shows how some ignore the sequence specificity question necessary for the informational code, and how this dilemma is being pushed to the extraterrestrial in a plea to the heavens.

Video Index:
00:00 - Introduction
00:47 - Reasons & Intent of this Abiogenesis Series
02:58 - On Speculatory Fallacies
06:26 - Synthetic Chemists: "Inconceivable"
10:36 - Interesting Proposal Still Falls Short
12:45 - Basics: Amino Acids, Peptides, Proteins
16:47 - Separating Amino Acids and Peptides
18:29 - Solid-Phase Peptide Synthesis
22:53 - Peptide Structures Explained
26:03 - Protein Synthesizer Machine Prebiotically Relevant?
30:57 - Peptide Synthesis: Requirements and Efficiency
38:23 - Pushing the Amino Acid Sequence to the Celestial
48:13 - Summary, Equilibrium Memo, and What's Next

Links in this Series | Addressing Abiogenesis & Common Misconceptions
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Series Trailer: https://youtu.be/N-RvMStTkx4
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0 - Reasons for this Series: https://youtu.be/71dqAFUb-v0
1 - Introduction to Abiogenesis: https://youtu.be/NqoVxwdWWpg
2 - Primordial Soup: https://youtu.be/tNbl-g8QoAg
3 - Hype: https://youtu.be/Q6b76XQQN00
4 - Homochirality: https://youtu.be/tqbpd3CmBgE
5 - Carbohydrates: https://youtu.be/rdqd_EvpsZM
6 - Building Blocks of Building Blocks: https://youtu.be/rdqd_EvpsZM
7 - Peptides: https://youtu.be/0Hv6KjB0j8Y
8 - Nucleotides: https://youtu.be/CYiguQYCSio
9 - Intermediate Summary & a Call to Colleagues: https://youtu.be/ImPxfmKrmoY
10 - Lipids: https://youtu.be/QTQd5Ifqv2g
11 - Chiral-induced Spin Selectivity: https://youtu.be/VKEZSfuMgL0
12.1 - Cell Construction & The Assembly Problem, Part 1: https://youtu.be/IaJo5jWs_6k
12.2 - Cell Construction & The Assembly Problem, Part 2: https://youtu.be/fDayvhch_W4
13 - Summary & Projections: https://youtu.be/71GTCHkId6M

Link to the cited video ("Elucidating the Agenda of James Tour: A Defense of Abiogenesis") can be found in the video description of Episode 0 - "Reasons for this Series" here: https://youtu.be/71dqAFUb-v0

The passionate thumbnail for this video uses a still frame image taken from Dr. Tour's video on Flash Graphene when he says "any" in the phrase "any carbon source" at 0:12: https://youtu.be/hhN5I_ocLSU

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God bless you.

#Abiogenesis #JamesTour #OriginOfLife

~
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