Why Fewer N-Antigen Antibodies in Double Dose Vaccinated?

Why Fewer N-Antigen Antibodies in Double Dose Vaccinated?

Someone sent the Vaccine Surveillence report for the week 42 issued by UK Health Security Agency. It states that there are fewer N-Antibodies after two dose vaccination. Let's review the mechanism.

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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

URL list from Friday, Jan. 21 2022

COVID-19 vaccine surveillance report - week 42
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1027511/Vaccine-surveillance-report-week-42.pdf

Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure | mSystems
https://journals.asm.org/doi/10.1128/mSystems.00095-21

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA | Nature Communications
https://www.nature.com/articles/s41467-021-21953-3

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 | Acta Pharmacologica Sinica
https://www.nature.com/articles/s41401-020-0485-4

Not just antibodies: B cells and T cells mediate immunity to COVID-19 | Nature Reviews Immunology
https://www.nature.com/articles/s41577-020-00436-4