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mothers at birth and also shortly thereafter through the milk. Vaccinations cannot effectively stimulate the kitten’s immune system until this maternal immunity wears off. Because maternal immunity declines slowly over time, kittens should be vaccinated according to a regular schedule, beginning at 2 to 3 months of age. This ensures that the kitten receives an effective dose of vaccine soon after maternal protection is gone. Restricting access to unvaccinated cats until the full series of vaccinations has been given is important to avoid disease.