Dr. Kevin McKernan raises several critical issues regarding the safety concerns of DNA contamination

Dr. Kevin McKernan raises several critical issues regarding the safety concerns of DNA contamination in mRNA vaccines, particularly with respect to Dr. Paul Offit's claims
1. Burden of Proof: Dr. McKernan argues that Dr. Offit should not simply assert that DNA integration into the human genome is "virtually impossible" without providing concrete evidence to back this claim. The scientific method, especially in contexts like vaccine safety, typically requires evidence to support safety assessments rather than assertions based on theoretical possibilities.

2. FDA Data Interpretation: The mention of the FDA study showing 4.7 micrograms of DNA per shot translates into a vast number of DNA molecules, highlighting the scale of potential contamination. This volume, particularly when considering the presence of SV40 promoters known for their nuclear targeting capabilities, suggests a need for more rigorous proof that these DNA fragments do not pose a risk.

3. SV40 Promoters: The presence of SV40 promoters, which are known components in gene therapy for their ability to target the nucleus, adds another layer of complexity to the safety debate. The assertion that these components could lead to genomic integration without definitive studies to disprove this possibility underscores the need for further investigation.

4. Cytosolic DNA and Pathways: Dr. McKernan references research (like Quan et al.) indicating that even if DNA does not integrate into the genome, its presence in the cytoplasm could activate pathways like cGAS-STING. Activation of such pathways can lead to cellular changes, including potential oncogenic effects, which complicates the narrative that only genomic integration is a concern.

5. Misdirection of Focus: Dr. McKernan's critique suggests Dr. Offit might be focusing too narrowly on genomic integration as the sole marker of risk, potentially overlooking other significant biological impacts of cytosolic DNA presence. This could be seen as a form of moving the goalposts, where the focus is shifted away from broader safety concerns to a specific, perhaps less likely, scenario." https://x.com/newstart_2024/status/1884290343530532871