Metagenomics, Microbiome Transmission, Gut Microbiome in Health & Disease | Nicola Segata | 203

Short Summary: A deep dive into the enigmatic world of sleep, exploring its biological functions, evolutionary origins, and diverse manifestations across different species.

About the Guest: Nicola Segata, PhD is a professor at the University of Trento in Italy.

Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and on YouTube. Partial versions are available elsewhere.

Episode Summary: Dr. Segata explains metagenomics, the study of genetic material from multiple species, and how it has revolutionized microbiome research; microbiome transmission from mother to child; stability and plasticity of the microbiome throughout life stages; obesity and cancer; influence of diet, lifestyle, and medications like antibiotics on microbiome composition.

Key Takeaways:

Microbiome Variability: The human microbiome varies significantly between individuals and is influenced by genetics, environment, diet, and lifestyle. Thus, personalized approaches to microbiome health may be necessary.

Transmission and Acquisition: Microbes are transmitted vertically from mother to child at birth and horizontally through personal interactions. This transmission can influence health outcomes over one's lifetime.

Impact of Diet and Drugs: Diet, particularly coffee consumption, can significantly shape the microbiome, with some bacteria growing in response to specific dietary components. Medications like antibiotics and proton pump inhibitors can also markedly alter microbial communities.

Health Implications: The microbiome is linked to various health conditions, from metabolic diseases to cancer, with some treatments like fecal microbiota transplantation showing promise in altering microbiome composition for health benefits.

Ancient vs. Modern Microbiomes: Studies on ancient microbiomes, like the Iceman's, suggest that modern urban microbiomes differ from those of our ancestors, potentially impacting modern health issues.

*Not medical advice.

00:00:00 Episode Intro
00:01:37 Human Microbiome Project
00:12:08 Data Analysis & Technological Advancements
00:12:28 Transmission of Microbiome Between Individuals
00:18:04 Impact of Antibiotics & Other Drugs on Microbiome
00:30:34 Microbiome & Disease Links
00:40:33 Ancient Microbiomes & Evolutionary Insights
00:44:20 Microbiome of Foods
01:11:54 Current & Future Research Directions