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Ward Dean MD | Dr Kennedy discusses NBMI ( Emeramide / OSR ) and Mitochondria
Mitochondria are small organelles found within cells, often referred to as the "powerhouse of the cell," responsible for generating most of the cell's chemical energy in the form of adenosine triphosphate (ATP) through a process called cellular respiration; they have a double membrane structure and contain their own DNA separate from the cell nucleus.
Mitochondria are extremely important because they are the primary organelles responsible for producing the majority of a cell's energy, in the form of ATP, which is crucial for all cellular functions and bodily processes; essentially acting as the "powerhouse" of the cell, making them vital for life.
Mercury is a toxic heavy metal that can damage mitochondria in several ways, including:
Disrupting the electron transport chain: Mercury can inhibit the activity of complex III and complex IV of the mitochondrial electron transport chain.
Depleting glutathione: Mercury can deplete glutathione, an antioxidant that protects against oxidative stress and inflammation.
Increasing ROS levels: Mercury can increase reactive oxygen species (ROS) levels.
Damaging the mitochondrial membrane: Mercury can change the permeability of the mitochondrial membrane.
Inducing mitochondrial swelling: Mercury can cause mitochondria to swell.
Cell death signaling: Mercury can signal apoptosis.
Mitochondrial dysfunction is one of the first consequences of mercury toxicity. Mercury has a high affinity for binding to sulfhydryl groups in mitochondria, which are present in amino acids, proteins, and enzymes. This binding can generate free radicals.
Chronic exposure to mercury can increase the risk of cardiovascular disease (CVD) and cerebrovascular accident (CVA).
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