Could Vortioxetine Be the Key to Beating Glioblastoma? 🧠

Glioblastoma (GBM) is one of the deadliest brain tumors, with limited effective treatments available. But new hope lies in drug repurposing—using already-approved medications in new, innovative ways to fight GBM.

One standout? Vortioxetine, a multimodal antidepressant. 💊

Key Highlights:

• Vortioxetine vs. GBM: This antidepressant is showing potent effects against GBM—inducing cell death, arresting tumor growth, and even enhancing the efficacy of chemotherapy like temozolomide.

• How It Works:

* Targets Serotonin Receptors: Modulates key serotonin pathways that overlap with glioblastoma growth.

* Induces Apoptosis: Promotes programmed cell death in tumor cells.

* Enhances Standard Treatments: Improves the sensitivity of GBM cells to radiation and chemotherapy.

• More Than a Mood Booster: Vortioxetine could potentially offer a dual benefit for GBM patients also experiencing mood disorders.

We’re seeing promising signs that drug repurposing could lead to faster, more effective treatments against one of the toughest cancers. Stay tuned for more groundbreaking insights!

➡️ Check out Off-ScriptRX through the link in my bio to read more on our blog and dive into the future of cancer care!

Supporting Evidence:

Lee, S., et al. (2024) High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity. Nature Medicine. doi.org/10.1038/s41591-024-03224-y.

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