New Research: Fatty Acids in Umbilical Cord Blood Could Cause Autism Spectrum Disorder

Scientists have unveiled a link between metabolites of fatty acids in cord blood and symptoms of autism spectrum disorder in children.
Autism spectrum disorder (ASD) is a neurodevelopmental condition that influences the learning abilities and social interactions of individuals. In recent decades, there has been a significant increase in awareness about ASD, including its occurrence and impact on those who are diagnosed. Nevertheless, many facets of ASD remain poorly understood, indicating that there is still much to learn.

Although the exact causes of ASD are unclear, currently available evidence points to neuroinflammation as a major factor. Several studies in mouse models of ASD have hinted at the importance of polyunsaturated fatty acids (PUFA) and their metabolites during pregnancy in playing a key role in ASD development. PUFA metabolites regulated by the cytochrome P450 (CYP) affect fetal development in mice causing impairments closely linked to ASD symptoms. However, it is still unclear if the same is true for humans and needs further investigation.