Approach to Jaundice - types and causes of hyperbilirubinemia, investigations

Approach to Jaundice - types and causes of hyperbilirubinemia, investigations

In this video, we dive deep into the world of jaundice, exploring the various types and causes of hyperbilirubinemia and the essential investigations needed for accurate diagnosis.

What You’ll Learn:
Understanding Jaundice:

Definition and basic physiology of bilirubin metabolism.
Visual signs and symptoms associated with jaundice.
Types of Hyperbilirubinemia:

Unconjugated Hyperbilirubinemia:
Causes: Hemolysis, Gilbert’s syndrome, Crigler-Najjar syndrome.
Pathophysiology and implications.
Conjugated Hyperbilirubinemia:
Causes: Biliary obstruction, hepatitis, Dubin-Johnson syndrome, Rotor syndrome.
Pathophysiology and implications.
Causes of Jaundice:

Pre-Hepatic Causes:
Increased bilirubin production due to hemolysis or ineffective erythropoiesis.
Hepatic Causes:
Liver diseases such as hepatitis, cirrhosis, and genetic disorders.
Post-Hepatic Causes:
Obstruction of bile flow due to gallstones, tumors, or strictures.
Investigations and Diagnostic Approach:

Laboratory Tests:
Bilirubin levels (total, direct, and indirect).
Liver function tests (AST, ALT, ALP, GGT).
Hemolysis markers (LDH, haptoglobin, reticulocyte count).
Imaging Studies:
Ultrasound, CT scan, MRCP to evaluate liver and bile ducts.
Special Tests:
Liver biopsy, genetic testing for specific syndromes.
Clinical Approach and Management:

Step-by-step clinical approach to diagnose the underlying cause of jaundice.
Overview of management strategies based on the etiology of hyperbilirubinemia.
Join us for an in-depth look at how to approach a patient with jaundice, understand the underlying mechanisms, and choose the right diagnostic tools to identify the cause of hyperbilirubinemia. This video is a comprehensive guide for medical students, healthcare professionals, and anyone interested in the clinical approach to jaundice.

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