Study: Treatment-Resistant Depression Linked to BMI

Recent research highlights a genetic contribution to treatment-resistant depression, linking it with several health disorders and suggesting new treatment possibilities based on shared genetic factors.
Genetic influences play a small yet important role in severe depression that is resistant to conventional treatments, say researchers from Vanderbilt University Medical Center and Massachusetts General Hospital.

The heritability of treatment-resistant depression (TRD) was found to have significant genetic overlap with schizophrenia, attention deficit disorder, cognitive, alcohol and smoking traits, and body mass index (BMI), suggesting a shared biology and, potentially, new treatment avenues.