Unwrap the TRAVERSE Study with Dr. George.

#trt #testosteronereplacementtherapy #testosterone

these are the main topics covered in this video:
1. traverse trial
2. traverse trial finds
3. Testosterone & Testosterone Replacement Therapy
4. The Testosterone Paradox
5. Bone Density Dilemma and Testosterone Replacement Therapy
6. Breaking Down the TRAVERSE Findings
7. Substudy Findings on Bone Fractures

Certainly! Here's a point-by-point summary of the discussion regarding the recent sub-study of the TRAVERSE trial and its findings on testosterone replacement therapy (TRT) and bone fractures:

1. **TRAVERSE Trial Context:**
- The TRAVERSE trial is a large study focusing on the effects of testosterone replacement therapy in men.
- It included around 5,000 participants and examined various health outcomes.
- The main study reported positive findings regarding TRT and cardiovascular health, suggesting no increased risk of cardiovascular disease in men on TRT compared to placebo.

2. **Substudy Findings on Bone Fractures:**
- A substudy of the TRAVERSE trial indicated a slightly higher incidence of bone fractures in men undergoing TRT.
- This finding seems counterintuitive, as TRT is generally believed to strengthen bones and muscles through the conversion of testosterone to estradiol.

3. **Study Design and Population:**
- Participants had low testosterone levels (as low as 10 nmol/L) to qualify for the study.
- The age range of the participants was broad, between 45 and 80 years old.

4. **Testosterone Treatment Used:**
- The form of TRT used in the study was a 1.62% testosterone gel, which is considered a low concentration.
- Participants were strictly monitored, and those with testosterone levels outside the range of 350-750 were dropped from the study.

5. **Criticism of Study Methodology:**
- The criticism is that the dosage of testosterone was too low to have a significant impact on bone density.
- The duration of the study (three years) may not have been long enough to observe improvements in bone density in individuals with osteoporosis.
- There is a suggestion that the study might have been set up in a way that could lead to misleading conclusions about TRT.

6. **Discussion with Dr. George:**
- Dr. George discusses the role of testosterone and estradiol in bone health, including the promotion of osteoblastic activity and calcium reabsorption.
- He mentions that the study did not provide enough time to establish a change in bone mineral density (BMD).
- There is a discussion about the importance of resistance training and adequate vitamin D3 and calcium levels for bone health.
- Dr. George also points out the paradoxical result of the study compared to the common understanding that androgens improve BMD.

7. **Statistical Significance and Fracture Locations:**
- The difference in fracture rates between the testosterone-treated group and the placebo group was only 1%.
- Fractures were more common in the ribs, wrists, and ankles, which could indicate other factors at play, such as age-related osteoporosis or low baseline testosterone levels.

8. **Conclusions and Recommendations:**
- The study is criticized for potentially drawing incorrect conclusions about TRT and bone health.
- It is recommended that men on TRT should not be overly concerned about bone fractures if they are being treated properly, and not with a low-dose testosterone gel.

Chapters
0:00 what is Traverse study?
2:55 why medical establishment are trying to demonize testosterone?
3:10 Bone mineral density?
4:33 the group that had the bone fracture is only 1% difference
5:46 10 NMOL/L quite a low level of testosterone
7:19 debunks the myths

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