Rare Longevity Mutation Linked to Unexpected Cardiovascular Benefits

A new study suggests that individuals with growth hormone receptor deficiency, also known as Laron syndrome, tend to have lower risk factors for cardiovascular disease compared to the average population.
A recent study suggests that individuals with a rare condition known as growth hormone receptor deficiency (GHRD), also referred to as Laron syndrome, may experience potential benefits for cardiovascular health.

GHRD, which is characterized by the body’s impaired ability to use its own growth hormone and results in stunted growth, has been linked in mice to a record 40% longevity extension and lower risks for various age-related diseases. However, the risk of cardiovascular disease in individuals with GHRD has remained unclear until now, leading to the speculation that in people, this mouse longevity mutation may actually increase cardiovascular disease.