TRT Thickens Bones + Caffeine Protective for TBIs + Cardarine / AICAR + Brown Fat (BioNews #7)

Citations:
Lalo, U., & Pankratov, Y. (2021). Astrocytes as Perspective Targets of Exercise-and Caloric Restriction‐Mimetics. Neurochemical Research, 1-14. https://link.springer.com/article/10.1007/s11064-021-03277-2
Ahmadinejad, M., & Ahmadipour, M. (2021). Effects of Caffeine administration on GCS and GOSE in children and adolescent patients with Moderate Brain Trauma. European Journal of Molecular & Clinical Medicine, 8(1), 1789-1794. https://ejmcm.com/article_8091.html
Aminian, M., Azarbayjani, M. A., Nemti, N. A., & BagherPoor, T. Interaction effect of 4 weeks aerobic training and octopamine on activity of brown adipose tissue of male rats fed with deep frying oil. Razi Journal of Medical Sciences, 0-0. http://rjms.iums.ac.ir/browse.php?a_id=6338&sid=1&slc_lang=en
Lassé, M., Pilbrow, A. P., Kleffmann, T., Överström, E. A., von Zychlinski, A., Frampton, C. M., ... & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific reports, 11(1), 1-10. https://www.nature.com/articles/s41598-021-84046-7
Ma, S. R., Yu, J. B., Fu, J., Pan, L. B., Yu, H., Han, P., ... & Wang, Y. (2021). Determination and Application of Nineteen Monoamines in the Gut Microbiota Targeting Phenylalanine, Tryptophan, and Glutamic Acid Metabolic Pathways. Molecules, 26(5), 1377. https://www.mdpi.com/1420-3049/26/5/1377
Apodaca, L. A., Al Anoud, D. B., Garcia, C., Alikhani, L., Giedzinski, E., Ru, N., ... & Baulch, J. E. (2021). Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer’s disease. Alzheimer's Research & Therapy, 13(1), 1-18.https://link.springer.com/article/10.1186/s13195-021-00791-x
Mele, C., Pingue, V., Caputo, M., Zavattaro, M., Pagano, L., Prodam, F., ... & Marzullo, P. (2021). Neuroinflammation and Hypothalamo-Pituitary Dysfunction: Focus of Traumatic Brain Injury. International Journal of Molecular Sciences, 22(5), 2686.https://www.mdpi.com/1422-0067/22/5/2686
Saravanan, J. (2021). Role of microgliosis, oxidative stress and associated neuroinflammation in the pathogenesis of Parkinson’s disease: The therapeutic role of Nrf2 activators. Neurochemistry International, 105014.https://www.sciencedirect.com/science/article/abs/pii/S0197018621000607
Tufekci, K. U., Ercan, I., Isci, K. B., Olcum, M., Tastan, B., Gonul, C. P., ... & Genc, S. (2021). Sulforaphane inhibits NLRP3 inflammasome activation in microglia through Nrf2-mediated miRNAs alteration. Immunology Letters.https://www.sciencedirect.com/science/article/abs/pii/S0165247821000407
Ng Tang Fui, M., Hoermann, R., Bracken, K., Handelsman, D. J., Inder, W. J., Stuckey, B. G., ... & Grossmann, M. (2021). Effect of Testosterone treatment on bone microarchitecture and bone mineral density in men: a two-year RCT. The Journal of Clinical Endocrinology & Metabolism.
https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgab149/6162862

Jax:
0:00 Intro
0:11 Cognitive reserve
1:12 Caloric restriction, environmental enrichment and neurodegeneration
3:09 Leo on this paper
3:42 Caffeine consumption and recovery from traumatic brain injury in adolescence
4:31 Caffeine problems in certain contexts
5:05 Uncoupling proteins, exercise and octopamine
5:49 Biomarkers and future cardiovascular events
6:14 The name Ma
6:28 Microbiomes and neurotransmitters
6:33 Gaba, tryptamine, catecholamines, and serotonin
6:54 Nervous system and gut microbiomes
7:20 lactobacillus plantarum
7:31 Phenylalanine, Tyrosine, L dopa, Dopamine, 3 methoxytyramine
8:13 Glutamic acid, tryptophan, 5htp, 5ht, 5hiaa, melatonin, kynurenine, and ken uric acid
9:17 stem cells and Alzheimer’s disease
9:34 5xfad mice
9:54 Stem cell derived extracellular vesicles
10:15 Beta amyloid plaque accumulation and microglial activity
10:40 Platelet rich plasma therapy
11:42 Inflammation and traumatic brain injuries
12:03 Hypo pituitary syndrome
13:16 Oxidative stress, gene pathway Nrf2, and Parkinson's disease
14:00 Sulforaphane and genes
14:14 IL 1beta and IL 18
14:37 Hypogonadal men, TRT and bone density

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