Cipro / Fluoroquinolones antibiotics real dangers

About Cipro, the antibiotics that was prescribed for Anthrax and that causes all the 'permanent' damages they are explaining and more : depersonalization (like the lady at the end of this clip), peripheral nerve damages, kills/depletes mitochondria, fibromyalgia, DNA breaks (children also affected), ripped tendon, mental disorders, just to name a few.

They changed the name of the antibiotic and the company but they are really talking about Cipro. And no, it's not a rare reaction at all (eventually 100%) and it's NOT on the side of the bottle! It's around page like 56 of the booklet that the doctor never reads, and the pharmacist is supposed to see the warning too, but Not the patient.

FDA internal documents note in 2013 that fluoroquinolones are toxic for mtDNA (p. 11-12-13, 24-25) and that various reactions from fluoroquinolones imply chronic multi-symptomatic symptoms typical to mtDNA damages.
"3.3.2 Possible Mechanism of Action: Mitochondrial Toxicity Fluoroquinolones act by inhibiting DNA gyrase and bacterial topoisomerase IV, both of which belong to the topoisomerase type IIA subfamily. Fluoroquinolones have been found to affect Mitochondrial conditions that are due to an insufficiency of ATP, especially in organs that rely on mitochondria for their energy source, include developmental disorders of the brain, optic neuropathy, neuropathic pain, hearing loss, muscle weakness, cardiomyopathy, and lactic acidosis. Neurodegenerative diseases, like Parkinson’s, Alzheimer’s, and amyotrophic lateral sclerosis (ALS) have been associated with the loss of neurons due to oxidative stress. ... please read here : http://www.myquinstory.info/wp-content/uploads/2014/12/FDA-PN-Memo.pdf (2013)

Health Canada says it too (2017) ( finally! Proven since 1989... : https://hpr-rps.hres.ca/reg-content/summary-safety-review-detail.php?lang=en&linkID=SSR00151

"Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in Ciprofloxacin-Treated Mammalian Cells" that was published in Molecular Pharmacology in 1996 ! (I printed it before it disappeared)

Cipro consistently proven scientifically to flox people, in clinically meaningful doses, in vitro and in vivo, like here:
Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells (2013)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/
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So it's Not Rare at all:
"Well over HALF of all fluoroquinolone antibiotics have been pulled from the market over the years for their horrific safety records--and those remaining (Cipro, Levaquin, Avelox and a few others) are no safer! A study of ADRs in Italy, published in 2005, found that among more than 50 types of drugs, fluoroquinolones were involved in the largest number of serious problems and accounted for 11 percent of all adverse events... Update: Cipro now carries TWO black box warnings!"
(http://www.ciproispoison.com/)

can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or low blood sugar. headache, irritability, numbness, tingling, confusion, agitation, problems with memory or concentration or sudden pain or movement problems in any of your joints.
https://www.drugs.com/ciprofloxacin.html

Mitochondrial dysfunction, post-exertional malaise and CFS/ME, by Lucy Dechene, Ph.D. March 31, 2014  https://www.prohealth.com/library/mitochondrial-dysfunction-post-exertional-malaise-and-cfs-me-32627 )(see refs)
 

Mitochondrial diseases caused by mtDNA mutations are unique because they are inherited in a maternal pattern. A mother can pass defective mtDNA to any of her children, but only her daughters—and not her sons—will pass it to the next generation.
https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Mitochondrial-Myopathy-Fact-Sheet

These Over-Prescribed Antibiotics are causing Transgenerational DNA damages
"In a May, 2014 letter to the U.S. Senate, Doctor Jay S. Cohen said of fluoroquinolones, “In my 40+ years in pharmacovigilance, FQs (fluoroquinolones) surpass Vioxx and Thalidomide in the degree of permanent harm done.” Let that sink in for a bit." and
"Many pharmaceuticals damage mitochondria. Not all of them interrupt the production of enzymes that are vital for the replication and transcription of DNA though. Fluoroquiolones do. They also form poisonous metabolites (thanks carboxylic acid molecule!) and leach all of the magnesium and iron out" ... and "I have argued that fluoroquinolones have transgenerational ill effects and that children are suffering because of the epigenetic effects of fluoroquinolones (HERE and HERE). I have never hoped to be wrong about anything more than my assertions that fluoroquinolones are related to autism, but the possibility exists – because we really don’t know what the transgenerational effects of microbiome destruction and depletion of mitochondrial DNA are – and fluoroquinolones do, indeed, both obliterate the microbiome and deplete the only non-redundant form of DNA that we have – mitochondrial DNA."
 https://www.scribd.com/document/239082168/These-Over-Prescribed-Antibiotics-Are-Causing-Transgenerational-DNA-Damage  or
https://www.wakingtimes.com/prescribed-antibiotics-causing-transgenerational-dna-damage/

The mental health side effects to be added to or updated across all the fluoroquinolones are disturbances in attention, disorientation, agitation, nervousness, memory impairment, and serious disturbances in mental abilities called delirium. https://www.fda.gov/drugs/drug-safety-and-availability/fda-reinforces-safety-information-about-serious-low-blood-sugar-levels-and-mental-health-side

FDA 2016 : peripheral neuropathy symptoms etc warning.
P.11: Fluoroquinolones, including CIPRO, have been associated with disabling and potentially irreversible serious adverse reactions from different body systems that can occur together in the same patient. Commonly seen adverse reactions include tendinitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and central nervous system effects (hallucinations, anxiety, depression, insomnia, severe headaches, and confusion). These reactions can occur within hours to weeks after starting CIPRO.
Patients of any age or without pre-existing risk factors have experienced these adverse reactions.
 https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019537s086lbl.pdf 

FDA 2013:
The risk of peripheral neuropathy occurs only with fluoroquinolones that are taken by mouth or by injection. http://wayback.archive-it.org/7993/20170112031629/http://www.fda.gov/Drugs/DrugSafety/ucm365050.htm

Peripheral neuropathy symptoms:
Every nerve in your peripheral system has a specific function, so symptoms depend on the type of nerves affected. Nerves are classified into:
Sensory nerves that receive sensation, such as temperature, pain, vibration or touch, from the skin
Motor nerves that control muscle movement
Autonomic nerves that control functions such as blood pressure, heart rate, digestion and bladder
Signs and symptoms of peripheral neuropathy might include:
Gradual onset of numbness, prickling or tingling in your feet or hands, which can spread upward into your legs and arms
Sharp, jabbing, throbbing or burning pain
Extreme sensitivity to touch
Pain during activities that shouldn't cause pain, such as pain in your feet when putting weight on them or when they're under a blanket
Lack of coordination and falling
Muscle weakness
Feeling as if you're wearing gloves or socks when you're not
Paralysis if motor nerves are affected
If autonomic nerves are affected, signs and symptoms might include:
Heat intolerance
Excessive sweating or not being able to sweat
Bowel, bladder or digestive problems
Changes in blood pressure, causing dizziness or lightheadedness
Peripheral neuropathy can affect one nerve (mononeuropathy), two or more nerves in different areas (multiple mononeuropathy) or many nerves (polyneuropathy). Carpal tunnel syndrome is an example of
https://www.mayoclinic.org/diseases-conditions/peripheral-neuropathy/symptoms-causes/syc-20352061

It's permanent: "All these FQ features strongly support the thesis that FQs can survive in the cell for a long time contributing to chronic, long-term adverse reaction in patients treated with FQs" and "1.4. Hepatotoxicity and Nephrotoxicity
The other adverse reactions generated by FQs include hepatotoxicity [21] and nephrotoxicity [22]. Golomb et al. [23] reported a case-series study and showed the potential occurrence of serious, persistent, and delayed multisymptom serious side effects apparently triggered by FQ use causing severe functional compromise and disability in previously vigorous, healthy individuals. In this study, Golomb et al. described patients who developed new-onset symptoms during and following FQ use. Domains of serious and persistent sequels included the better-recognized tendon and muscle issues but extended to the well-reported but still often unappreciated potential for cognitive, psychiatric, peripheral nervous, and gastrointestinal issues as well as endocrine issues." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/ (2017)

Cipro Warning: https://www.rxlist.com/cipro-drug.htm

Hundreds of more studies show FQ can do that to us: https://floxiehope.com/fluoroquinolones-links-resources/

Case report: with progression that continued following discontinuation evolving to a severe, disabling multisymptom profile variably involving tendinopathy, muscle weakness, peripheral neuropathy, autonomic dysfunction, sleep disorder, cognitive dysfunction and psychiatric disturbance. Physicians and patients should be alert to the potential for FQ-induced severe disabling multisymptom pathology that may persist and progress following FQ use. Known induction by FQs of delayed mitochondrial toxicity provides a compatible mechanism, with symptom profiles (and documented mechanisms of FQ toxicity) compatible with the hypothesis of an exposure-induced mitochondrial neurogastrointestinal encephalomyopathy. https://casereports.bmj.com/content/2015/bcr-2015-209821

Here is another case study of patient having symptoms of chronic fatigue syndrome, fibromyalgia that turned out to be mitochondrial myopathy
Link: https://link.springer.com/article/10.1186/1752-1947-6-55