Long Story Short Episode 85: mRNA Vaccines Produce Off-Target Proteins

What are the off-target proteins produced by mRNA vaccines? Can these proteins cause harm? What is the mechanism of their production? Let's review.

An article on University of Cambridge contains this statement, "Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics."

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Friday, Dec. 15, 2023

Long Story Short With Dr. Been - FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/courses/long-story-short-with-dr-been/

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses | University of Cambridge
https://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses

N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting | Nature
https://www.nature.com/articles/s41586-023-06800-3

Interferon gamma - Wikipedia
https://en.wikipedia.org/wiki/Interferon_gamma

The Shape and Structure of Proteins - Molecular Biology of the Cell - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK26830/#:~:text=A%20protein%20molecule%20is%20made,one%20molecule%20to%20the%20next.

Ribosomes, Transcription, Translation | Learn Science at Scitable
https://www.nature.com/scitable/topicpage/ribosomes-transcription-and-translation-14120660/#:~:text=Recall%20that%20mRNA%20molecules%20are,protein%20as%20it%20is%20synthesized.

Genetic code - Wikipedia
https://en.wikipedia.org/wiki/Genetic_code

DNA and RNA codon tables - Wikipedia
https://en.wikipedia.org/wiki/DNA_and_RNA_codon_tables

Pseudouridine - Wikipedia
https://en.wikipedia.org/wiki/Pseudouridine

Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines | ACS Central Science
https://pubs.acs.org/doi/10.1021/acscentsci.1c00197

Ribonucleotide - Wikipedia
https://en.wikipedia.org/wiki/Ribonucleotide#:~:text=In%20biochemistry%2C%20a%20ribonucleotide%20is,monomeric%20building%20blocks%20for%20RNA.

Translation: DNA to mRNA to Protein | Learn Science at Scitable
https://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/#:~:text=The%20process%20of%20translation%20can,transcription%20as%20well%20as%20tRNA.&text=The%20genes%20in%20DNA%20encode,the%20functions%20necessary%20for%20life.

Frontiers | On programmed ribosomal frameshifting: the alternative proteomes
https://www.frontiersin.org/articles/10.3389/fgene.2012.00242/full#:~:text=Frameshifting%20is%20a%20process%20whereby,downstream%20(%E2%88%921%20frameshift).

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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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