Prof. Yoichiro Sugiyama @ FLOGEN SIPS 2022 Yoshikawa Intl. Symposium on Oxidative Stress
FLOGEN SIPS 2022: Yoshikawa International Symposium on Oxidative Stress for Sustainable Development of Human Beings (2nd international Symposium)
Presenter:
Prof. Yoichiro Sugiyama, Department of Otolaryngolgy-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
Title:
The effect of antioxidant Twendee X on swallowing function in an animal model of dysphagia in guinea pigs
Abstract
Dysphagia is one of the significant concerns in the aging society. In particular, the elderly with swallowing impairment caused by either central or peripheral nervous systems has difficulty in oral intake, possibly resulting in fatal pneumonia. As such, the development of a therapeutic approach that decreases in the risk of aspiration in dysphagic patients remains a pressing issue for medical doctors. The purpose of our study was to establish the animal model of dysphagia and test the hypothesis that decreased pharyngeal constriction caused by the denervation of the vagal efferent nerves can be improved by the application of the anti-oxidant agent. Thus, we developed the animal model in guinea pigs in which the pharyngeal branch of the vagus nerve was cut and initially evaluated swallowing function using videofluoroscopy. We then tested the effect of oral application of the anti-oxidant agent Twendee X on swallowing function in the dysphagia model animals. Insufficient pharyngeal constriction and pharyngeal residue were found in the denervated animals. The swallowing dysfunction was less pronounced in dysphagic animals with the administration of Twendee X. In conclusion, Twendee X could have a possible role in the improvement of swallowing function in dysphagic patients with decreased swallowing muscle strength caused by neuromuscular atrophy.
-
2:14:17
AP4Liberty
2 hours agoTrump Leads Harris in Key Battleground States
3.51K1 -
2:23:24
Game On!
14 hours agoLet's be honest, the NFL misses Tom Brady
14.5K2 -
12:51
Adam Does Movies
18 hours agoAm I Racist? Movie Review - Is This Funny?
28.1K17 -
38:20
Degenerate Plays
18 hours agoDoctor, Doctor, Give Me The News - Assassin's Creed : Part 12
21.1K2 -
24:37
GameLeap RAID Shadow Legends
19 hours ago15 BEST EPICS You MUST MAX in 2024 (Every Faction) - Raid Shadow Legends Tier List
18.5K1 -
15:50
RealitySurvival
13 hours agoKeystone Meats - Next Level Long Term Food Storage!
15.7K5 -
2:48:50
vivafrei
1 day agoEp. 229: P Diddy DENIED BAIL! Pool SUES Kamala Harris! Jamie Raskin "DISQUALIFYING" Trump & MORE!
191K392 -
1:59:11
Nerdrotic
16 hours agoAncient Apocalypse Returns - Atlantis Puzzle Review | Forbidden Frontier #075
191K26 -
LIVE
Vigilant News Network
23 hours agoVaccine Horror Shocks the World: Exclusive Update - Media Blackout
1,744 watching -
1:25:19
Josh Pate's College Football Show
15 hours agoTennessee Silences OU | Michigan Beats USC | Hugh Freeze Problem | Early UGA-Alabama Thoughts
92.4K13