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Dual Mechanism of Action:
Metformin primarily works by reducing the production of glucose in the liver and improving insulin sensitivity in peripheral tissues. Glipizide, on the other hand, stimulates the release of insulin from the pancreas. Combining both medications addresses multiple aspects of glucose control.
Improved Blood Sugar Control:
The combination of metformin and glipizide is effective in lowering blood sugar levels, helping individuals achieve better glycemic control.
Reduced Risk of Hypoglycemia:
Metformin does not typically cause hypoglycemia (low blood sugar) when used alone. By combining it with glipizide, which stimulates insulin release, the risk of hypoglycemia may be reduced compared to using glipizide alone.
Enhanced Insulin Sensitivity:
Metformin's insulin-sensitizing effects complement the insulin-stimulating effects of glipizide, potentially improving overall insulin function.
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