Premium Only Content
NIH, Wuhan were working on monkeypox
Wuhan Institute of Virology published on monkeypox research 3 months ago, NIH also have been researching monkeypox treatment
https://reporter.nih.gov/search/sLt35...
Total funding, $9,824,009
The funding supports a clinical trial to identify effective treatments for monkeypox
A re-emerging pathogen
A disease of epidemic potential
Causes significant morbidity and can result in death
Human cases have been increasing in sub-Saharan Africa since 2000
Sporadic outbreaks outside of Africa have occurred
Similarity between MPXV and the variola virus,
coupled with concerns about the potential of the variola virus as a potential bioterrorism agent,
have placed monkeypox treatments at the forefront of public health and scientific research agendas in many countries.
Article in Virologica Sinica?
https://www.sciencedirect.com/science...
Efficient assembly of a large fragment of monkeypox virus genome as a qPCR template using dual-selection based transformation-associated recombination (Feb 2022)
Since MPXV infection has never been associated with an outbreak in China, the viral genomic material required for qPCR detection is unavailable.
Using viral DNA recombinations
Transformation-associated recombination (TAR),
to assemble large DNA constructs
A 55-kb genomic fragment of monkeypox virus in VL6-48B (yeast cells)
What is Virologica Sinica?
https://www.sciencedirect.com/journal...
Virologica Sinica, the official journal of Chinese Society for Microbiology,
will serve as a platform for the communication and exchange of academic information and ideas in an international context.
Discussion section
However, this DNA assembly tool applied in virological research could also raise potential security concerns,
especially when the assembled product contains a full set of genetic material that can be recovered into a contagious pathogen.
Recently, a group of scientists was funded by a biotech company to synthesize a full-length horsepox virus genome and recover it into an infectious virus (Noyce et al., 2018).
Not surprisingly, such a controversial achievement has received enormous attention and raised global debate on its biosecurity implications (DiEuliis et al., 2017; Koblentz, 2017, 2018; DiEuliis and Gronvall, 2018).
In this study, although a full-length viral genome would be the ideal reference template for detecting MPXV by qPCR, we only sought to assemble a 55-kb viral fragment, less than one-third of the MPXV genome.
This assembly product is fail-safe by virtually eliminating any risk of recovering into an infectious virus while providing multiple qPCR targets for detecting MPXV or other Orthopoxviruses (Li et al., 2010).
Our world in data monkeypox
https://ourworldindata.org/explorers/...
Spain and Belgium ‘gay events’
UK
Cases, + 11 = 190
20,000 doses of a smallpox vaccine
offered to close contacts of those diagnosed with monkeypox
reduce the risk of symptomatic infection and severe illness
Dr Rosamund Lewis, WHO
It's very important to describe this because it appears to be an increase in a mode of transmission that may have been under-recognised in the past
unfortunate if monkeypox exploit the immunity gap left by smallpox 40 years ago
there is still a window to close the outbreak
-
2:48
Steven Crowder
11 hours agoCROWDER CLASSICS: What’s This? | Nightmare Before Kwanzaa (Nightmare Before Christmas Parody)
182K12 -
LIVE
LFA TV
12 hours agoLFA TV CHRISTMAS EVE REPLAY
888 watching -
UPCOMING
tacetmort3m
20 hours ago🔴 LIVE - THE ZONE KEEPS PULLING ME BACK - STALKER 2 - PART 15
69 -
22:45
Brewzle
9 hours agoI Went Drinking In A Real Bourbon Castle
2561 -
48:36
PMG
1 day ago $0.06 earned"Parkland Parent Speaks Out On Kamala Harris Using Victims"
410 -
4:06
The Lou Holtz Show
7 hours agoCoach Lou Holtz’s Heartfelt Christmas Message 🎄 | Family, Faith & Notre Dame Spirit 💚 #christmas
63 -
51:35
Dr Steve Turley
1 day ago $13.12 earnedROSEANNE BARR - Her Journey, TRUMP, and the MAGA GOLDEN AGE! [INTERVIEW]
31.9K47 -
57:38
The Tom Renz Show
5 hours agoMerry Christmas - The Tom Renz Show Christmas
60.4K14 -
2:59:10
Wendy Bell Radio
16 hours agoThe Bridge Too Far
145K289 -
1:03:45
Donald Trump Jr.
1 day agoHappy Festivus: Airing Our Grievances and Stopping The Swamp w/Sean Davis | TRIGGERED Ep.201
410K535