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Are you on acid (blockers)?
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I can't believe they give these things to infants.
Here's what the manufacturer says: https://www.rxlist.com/omeprazole/generic-drug.htm
Long-term Effects
Increased risk for osteoporosis-related fractures of the hip, wrist, or spine with prolonged use (over 1 year) with high-dose therapy.
Magnesium deficiency in the blood may occur with prolonged use (over 1 year); adverse effects may result and include muscle spasms, irregular heartbeat, and seizures; in 25% of cases reviewed, magnesium supplementation alone did not improve low serum magnesium levels and the PPIs to be discontinued.
Daily long-term use (more than 3 years) may lead to malabsorption or a deficiency of cyanocobalamin.
See "What Are Side Effects Associated with Using Omeprazole?"
Cautions
PPIs are possibly associated with increased incidence of Clostridium difficile-associated diarrhea; consider the diagnosis for patients taking this drug who have diarrhea that does not improve.
May require dosage reduction with liver disease.
Cutaneous lupus erythematosus and systemic lupus erythematosus reported with PPIs; avoid using for longer than medically indicated; discontinue if signs or symptoms consistent with either condition are observed and refer the patient to a specialist.
Shown to cause gastric carcinoid tumors in rats with increased doses, but the risk in humans is unconfirmed.
Published observational studies suggest that proton pump inhibitors therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine, particularly with prolonged (over 1 year), high-dose therapy.
Magnesium deficiency in the blood may occur with prolonged use (over 1 year); adverse effects may result and include muscle spasms, irregular heartbeat, and seizures; in 25% of cases reviewed, magnesium supplementation alone did not improve low serum magnesium levels and the proton pump inhibitors had to be discontinued.
Decreased gastric acidity increases serum chromogranin A levels and may cause false-positive diagnostic results for neuroendocrine tumors; temporarily discontinue proton pump inhibitors before assessing serum chromogranin A levels.
Inhibits hepatic isoenzyme CYP2C19 and may alter the metabolism of drugs that are CYP2C19 substrates.
PPIs may decrease the efficacy of clopidogrel by reducing the formation of the active metabolite.
Daily long-term use (more than 3 years) may lead to malabsorption or a deficiency of cyanocobalamin.
Acute interstitial nephritis has been observed in patients taking PPIs.
Relief of symptoms does not eliminate the possibility of gastric malignancy.
Therapy increases the risk of Salmonella, Campylobacter, and other infections.
May elevate and/or prolong serum concentrations of methotrexate and/or its metabolite when administered together with proton pump inhibitors, possibly leading to toxicity; consider a temporary withdrawal of PPIs therapy with high dose methotrexate administration.
Pregnancy and Lactation
Use this drug with caution in pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies are done.
Omeprazole distributes into human breast milk; use caution if breastfeeding. Breast milk peak concentration time approximately 3 hours following 20 mg dose (peak concentration less than 7% of peak serum concentrations).
Because of the potential for serious adverse reactions in nursing infants from omeprazole, and the potential for tumorigenicity shown in rat carcinogenicity studies, a decision should be made to discontinue nursing or to discontinue use, taking into account the importance of the drug to the mother.
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