Long Story Short Episode 68: Intermittent Fasting and Alzheimer's Disease

n this fascinating study from UCSD, researchers demonstrate for the first time that time-restricted-feeding (TRF), or intermittent fasting, can synchronize neuronal tissue clocks. This results in the Alzheimer's disease mice to have better sleep, improved sleep length, less irritability, better metabolic dynamics, reduced plaque load and improved plaque clearance, and improved abeta42/abeta40 ratio, with memory improvements almost equal to healthy mice. Let's review.

DrBeen: Medical Education Online
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FLCCC | Front Line COVID-19 Critical Care Alliance
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References (Aug. 25, 2023)

URCircadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S1550413123002735?via%3Dihub

Overview of Circadian Rhythms - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707128/#:~:text=Light%20represents%20the%20most%20important%20Zeitgeber.&text=A%20standardized%2024%2Dhour%20notation,night%2C%20or%20the%20dark%20phase.

Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses - PubMed
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Zeitgeber times (ZT) when NOR tasks were carried out. ZT 0 corresponds... | Download Scientific Diagram
https://www.researchgate.net/figure/Zeitgeber-times-ZT-when-NOR-tasks-were-carried-out-ZT-0-corresponds-to-the-time-when_fig3_269725496

What's Tau Got to Do With it? - InVivo Biosystems
https://invivobiosystems.com/disease-modeling/whats-tau-got-to-do-with-it/

Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment - PubMed
https://pubmed.ncbi.nlm.nih.gov/17374949/

[PDF] Reviewing reasons for the decreased CSF Abeta42 concentration in Alzheimer disease. | Semantic Scholar
https://www.semanticscholar.org/paper/Reviewing-reasons-for-the-decreased-CSF-Abeta42-in-Spies-Verbeek/456bb3440bdfac62a65d997fca7992ebba9a2dcc

The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study - PMC
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High Morning Blood Glucose | ADA
https://diabetes.org/diabetes/treatment-care/high-morning-blood-glucose#:~:text=into%20dangerous%20territory.-,The%20dawn%20phenomenon,blood%20glucose%20levels%20in%20check.

Somogyi Effect: What It Is, Causes, Symptoms & Treatment
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Case Report: Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194375/

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics - PMC
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Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics - PMC
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IJMS | Free Full-Text | Phosphorylation Signaling in APP Processing in Alzheimer’s Disease
https://www.mdpi.com/1422-0067/21/1/209

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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