Long Story Short Episode 63: Anti-Inflammatory Effects of Ashwagandha

Ashwagandha is an herb that has been used in Indian (Ayurvedic) medicine for nearly 3000 years. It is found in India (native), the Middle East, and Africa. It is reported to have anti-inflammatory, anti-microbial, anti-diabetic, anti-hypertensive, neuroprotective, apoptogenic, and reproductive and hormone-modulating effects. In this episode, we will review the anti-inflammatory aspects of ashwaganda and specifically, will discuss NF-kB pathway modulation.

URL list from Thursday, July 20, 2023

Home - FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
https://www.mdpi.com/1999-4923/15/4/1057

Ashwagandha - Special Subjects - Merck Manuals Consumer Version
https://www.merckmanuals.com/home/special-subjects/dietary-supplements-and-vitamins/ashwagandha

Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines
https://www.spandidos-publications.com/ijmm/42/1/425

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-020-00312-6

Frontiers | NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration
https://www.frontiersin.org/articles/10.3389/fimmu.2019.00705/full

fimmu-10-00705-g002.jpg (1084×813)
https://www.frontiersin.org/files/Articles/443978/fimmu-10-00705-HTML/image_m/fimmu-10-00705-g002.jpg

fimmu-10-00705-g001.jpg (1084×813)
https://www.frontiersin.org/files/Articles/443978/fimmu-10-00705-HTML/image_m/fimmu-10-00705-g001.jpg

Frontiers | What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?
https://www.frontiersin.org/articles/10.3389/fcell.2019.00154/full#:~:text=Nuclear%20factor%20kappa%20B%20(NF%2D%CE%BAB)%20is%20an%20ancient,cellular%20resistance%20to%20invading%20pathogens

IκBα - Wikipedia
https://en.wikipedia.org/wiki/I%CE%BAB%CE%B1

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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