Neuromuscular Blocking Agents (Definition) | Depolarizing vs Nondepolarizing Drugs

What are Neuromuscular Blocking Agents? What is the difference between Depolarizing and Nondepolarizing Drugs?
💥Neuromuscular Blocking Agents [Full Guide] ➜ ➜ ➜ https://bit.ly/2xGMzQw

➡️ Neuromuscular Blocking Agents Definition
These are a class of medications that cause paralysis of skeletal muscle tissues. They work by altering the action of the post-synaptic acetylcholine receptors. This causes paralysis of the muscles of respiration which is why mechanical ventilation is required whenever a neuromuscular blocking agent has been administered. These drugs are often given to facilitate intubation and improve the surgical condition of pre-operative patients. Keep in mind that these patients, while paralyzed, will still be fully aware. This is why analgesics and general anesthetics must be given as well along with neuromuscular blocking agents.

➡️ Types of Neuromuscular Blocking Agents:
- Depolarizing Agents
- Nondepolarizing Agents

➡️ What are Depolarizing Agents?
As the name suggests, depolarizing agents cause rapid depolarization which makes the muscle fibers resistant to stimulation by Acetylcholine. They provide a rapid onset and a short duration that lasts only 7-12 minutes. An example of a depolarizing neuromuscular blocking agent is Succinylcholine (Anectine).

➡️ What are Nondepolarizing Agents?
Nondepolarizing agents, on the other hand, cause total paralysis by blocking the binding of acetylcholine and the inotropic activity of Ach receptors. The onset of this type is rapid as the medication takes effect within minutes, although not as rapid as depolarizing agents that work in a matter of seconds. The duration is longer as well, lasting from 30 minutes up to 2 hours.

➡️ Some examples of nondepolarizing neuromuscular blocking agents include the following:
- Cisatracurium (Nimbex)
- Pancuronium (Pavulon)
- Rapacuronium (Raplon)
- Mivacurium (Mivacron)
- Atracurium (Tracrium)
- Vecuronium (Norcuron)
- Rocuronium (Zemuron)

Another important tidbit to remember is that nondepolarizing agents can be reversed with anticholinesterase inhibitors. Again, we created this video just to provide you with a brief overview of this topic. We'll be breaking it down into much more detail in a separate video.

💥Neuromuscular Blocking Agents [Full Guide] ➜ ➜ ➜ https://bit.ly/2xGMzQw

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🚑MEDICAL DISCLAIMER
This content is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult with a physician with any questions that you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you watch in this video. We strive for 100% accuracy, but errors may occur, and medications, protocols, and treatment methods may change over time.

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⏰TIMESTAMPS
0:00 - Intro
0:24 - Neuromuscular Blocking Agents Definition
1:07 - Types of Neuromuscular Blocking Agents
1:18 - What are Depolarizing Agents?
1:40 - What are Nondepolarizing Agents?
2:06 - Examples of Nondepolarizing Neuromuscular Blocking Agents

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