How to Reduce the Severity of Age-Related Diseases & Increase Longevity

A new study has investigated the measurable effects that poor mental health can have on the severity of certain age-related diseases.
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Links:
https://www.nature.com/articles/s41467-023-38013-7
https://pubmed.ncbi.nlm.nih.gov/37080981/
https://rb.gy/sfz1r
https://europepmc.org/article/PMC/PMC10119095
https://rb.gy/7tub4
https://rb.gy/is1d7
https://onlinelibrary.wiley.com/doi/10.1111/acel.13610
https://ehp.niehs.nih.gov/doi/10.1289/EHP10391

A study just released by the Columbia Mailman School of Public Health and the Peking University School of Public Health provides some of the first, large-scale evidence that some processes of biological aging may contribute to the risk of depression and anxiety. Until now nearly all work to date has focused on poor mental health as a risk factor for accelerated aging. A complementary, but less-studied hypothesis is that the reverse process may also occur, and accelerated processes of biological aging may, themselves, pose risks to depression/anxiety disorders in older adults. The researchers tested associations of blood-chemistry measures of biological aging with prevalent and incident depression and anxiety among a half-million midlife and older adults. The study used the UK Biobank, an ongoing study with 502,536 participants recruited between 2006 and 2010 with an age range of between 37 and 73; the study included multiple follow-ups. The findings showed that adults with more advanced biological age were more likely to experience depression and anxiety at baseline. These adults were also at higher risk of depression and/or anxiety over the eight-year follow-up period. This was when compared to peers who were the same chronological age, but who were tested to be biologically younger. At the 8.7 year-follow up point, participants with an older biological age were at a 6% increased risk of incident depression and/or anxiety.
Xu Gao, Ph.D., First Author of the study and an Assistant Professor in the Department of Occupational & Environmental Health Sciences, at the School of Public Health, Peking University said "Among older adults who were free of depression and/or anxiety at baseline, those whose blood indicated that they were biologically older than their chronological age were predicted as more likely to develop depression or anxiety over the follow-up compared with those whose blood indicated that they were biologically younger."
Depression and anxiety are common mental disorders that can very often co-occur, and are associated with increased disability and mortality, especially in older adults. It therefore follows that prevention of depression and anxiety in older adults has the potential to mitigate the burden of age-related diseases in an aging population.
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