Estrogen Control on TRT: AIs and Bone Mineral Loss?

In this vid, we'll discuss the use of Aromatase inhibitors, and specifically anastrazole, and how that may or may not contribute to bone mineral density loss while on TRT (as well as how to mitigate this potential risk).

Sources for points made and studies referenced:

1. Management of Aromatase inhibitor induced Arthralgia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826784/
2. The Utilization and Impact of Aromatase Inhibitor Therapy in Men With Elevated Estradiol Levels on Testosterone Therapy: https://www.researchgate.net/publication/352104099_The_Utilization_and_Impact_of_Aromatase_Inhibitor_Therapy_in_Men_With_Elevated_Estradiol_Levels_on_Testosterone_Therapy
3. Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893665/
4. Strontonium's effect on increasing bone mineral density:
https://www.nejm.org/doi/full/10.1056/nejmoa022436#:~:text=In%20this%20study%2C%20strontium%20ranelate,proportional%20to%20bone%20mineral%20density
5. Effect of Anastrozole on Bone Mineral Density: 5-Year Results From the Anastrozole, Tamoxifen, Alone or in Combination Trial 18233230: https://ascopubs.org/doi/10.1200/JCO.2007.11.0726

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00:00 Male Performance essentials
01:00 Controversy around aromatase inhibitors on TRT
02:35 Ryan's take on AI use on TRT
03:23 How Anastrazole works
04:20 For some men, Anastrazole will cause symptoms
04:45 Joint pain on AIs explained
06:24 AIs and bone mineral density research
07:54 Incorrect dosing among redditers and their feedback
08:42 Men are dosing anastrazole wrong (sometimes)
10:07 A strategy for dosing anastrazole on TRT
11:28: Consider not just the half-life but full life of anastrazole
12:43 Where men go wrong with aromatase inhibitor dosing
15:35 Why men end up on Danny Bossa and crew's ideology
16:05: How to mitigate bone risks on aromatase inhibitors
17:39 EPA/DHA dense fish oil aids bone mineral density
17:55 Strontonium to increase bone mineral density
20:35 Hire Ryan for your TRT protocol
20:58 Nootropic stacks