Erythritol and Heart Attacks

'Go natural': Common zero-calorie sweetener may increase risk for cardiac events

The unbiased approach was mass spectrometry, Hazen said. In initial untargeted metabolomics studies among patients undergoing cardiac risk assessment, the researchers found that circulating levels of multiple polyol sweeteners — particularly erythritol — were connected with incident risk for major adverse cardiovascular events (MACE).

These results were then replicated in a large cohort in the United States and again in a large European cohort. Compared with patients in the lowest quartile of erythritol levels, those in the highest quartile had adjusted HRs of 1.8 (95% CI, 1.18-2.77) in the U.S. cohort and 2.21 (95% CI, 1.2-4.07) in the European cohort.

The researchers additionally took blood from volunteers without CVD or diabetes to see how erythritol levels would impact other populations.

Hazen and colleagues ultimately found that, after erythritol consumption, “a prolonged period of potentially heightened thrombotic risk may occur,” which is concerning, they wrote, given that the people who are usually the targets of artificial sweetener marketing — those with obesity, diabetes or who have a history of CVD — are the same patients who are typically at risk for future CVD events.

https://www.healio.com/news/primary-care/20230301/go-natural-common-zerocalorie-artificial-sweetener-increases-risk-for-cardiac-events?utm_source=selligent&utm_medium=email&utm_campaign=news&M_BT=7818380669159

https://www.medscape.com/viewarticle/988721?src=FYE

Aspartame
https://www.medscape.com/viewarticle/985861?src=wnl_sci_tech_221221_MSCPEDIT&uac=180486SK&impID=5010101

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227014/

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