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It is recommended for children with seizures that are refractory to treatment, that is, they do not respond to several different anticonvulsant medications. It has primarily been used in some situations, however it is particularly recommended for children with Lennox-Gastaut syndrome. It is also suitable for certain types of seizures or epileptic syndromes, being useful for: Myoclonic epilepsy of childhood (Dravet syndrome), Myoclonic astatic epilepsy (Doose syndrome), infantile spasms (West syndrome), Mitochondrial defects, Tuberous sclerosis or tuberous sclerosis complex (TSC), Rett syndrome. And for GLUT 1 deficiency syndrome (GLUT1 DS) and pyruvate dehydrogenase (PDH) deficiency.
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