NO Exercise | But Improved Mitochondrial Health & Muscle Endurance (Urolithin A)

This supplement was approved by the FDA in 2018, it has the ability to restore the mitochondria; Mitochondrial dysfunction being one of the nine ‘hallmarks of aging.’
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Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133463/
https://pubmed.ncbi.nlm.nih.gov/35050355/
https://pubmed.ncbi.nlm.nih.gov/35584623/
https://pubmed.ncbi.nlm.nih.gov/35778837/
https://pubmed.ncbi.nlm.nih.gov/28757461/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417212/
https://www.clinicaltrials.gov/ct2/show/NCT04783207
https://clinicaltrials.gov/ct2/show/NCT03464500
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244
http://pdf.amazentis.com/pdf/Amazentis_Timeline_Launch_PR_7.27.2020_v9_Final.pdf
Mukku, Murray, Espin, & Perdew (2018), “Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist”, NCBI
Singh, Andreux, Blanko, Auwerx, & Rinsch (2019), “Urolithin A, a Gut Microbiome Derived Metabolite”, Academic
D’Amico, Andreux, Valdes, Singh, Rinsch, & Awerex (2021), “Impact of the Natural Compound Urolithin A on Health, Disease, and Aging”, Science Direct
Aebischer, Blanco-bose, Kern, Dunngalvin, Andreux, D’Amico, Singh, & Rinsch (2021), “Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability”, Nature

What is Urolithin A, how do we produce it, and can everybody produce it naturally? Urolithin A is a naturally derived nutrient which is processed by microflora in our gut microbiome (microflora are bacteria and microscopic algae). Urolithin A is a postbiotic (I’m sure you have heard of prebiotics and probiotics) - Urolithin A is synthesized after eating certain foods high in polyphenols like berries, nuts and pomegranates.
Postbiotics are by-products from the gut that can act as health-promoting compounds. Taking a supplement for this nutrient may necessary as not everyone nowadays is capable of producing it naturally.
Research has revealed that only 12% of people are proficient in producing Urolithin A naturally in the body. Unfortunately, our mitochondrial function declines with age, impairing the mitochondria’s ability to produce enough energy for our bodies to function as they did in our youth. Mitochondrial dysfunction is one of the nine ‘hallmarks of aging’ that cause cellular and molecular damage to the body that can lead to age-related illness. Known as an antagonistic hallmark, mitochondrial dysfunction can cause loss of muscle strength, which many people experience from their 40’s onwards. This can lead to a serious condition known as sarcopenia that affects 30% of older people and is associated with poor mobility, frailty and fall-related injuries. For those who are less physically able, Urolithin A can be used to boost mitochondrial health without the need for exercise. Available from the diet and more effectively, from dietary supplements, Urolithin A has been shown to promote mitochondrial health and muscle endurance. It does this by improving mitochondrial activity, specifically by activating the process of mitophagy.
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