cas: 5630-53-5 tibolone tablets

cas: 5630-53-5 tibolone tablets

Tibolone works by mimicking the activity of the female sex hormones, oestrogen and progesterone. It also has some male hormone (androgen) effects. Tibolone helps to restore the balance of female hormones in women who have a lack of oestrogen; it helps to ease symptoms such as hot flushes and night sweats. You will only be prescribed it if these symptoms seriously interfere with your daily life.

Tibolone is used as a part of hormone replacement therapy to relieve symptoms of menopause such as hot flushes, vaginal dryness, depression, and night sweats.

It may also be used for preventing osteoporosis in women who have attained menopause and are at high risk of fractures.

Take it at the same time everyday to help you remember to take it.

It may cause bleeding or spotting in between menstrual periods. Let your doctor know if this occurs frequently.

Stop taking Tibolone and inform your doctor immediately if you get severe headaches, stabbing pains or swelling in one leg, and pain on breathing. These could be symptoms of a blood clot in a vein.

Ensure that you regularly check your breasts for any changes and undergo regular breast screening and cervical smear tests while on treatment with this medicine.

Do not use Tibolone if you have a history of blood clots and liver disease.

Tibolone is a synthetic steroid molecule which is, in essence, a progestogen. Post absorption, its metabolites have oestrogenic, progestogenic and androgenic properties (1, 2). The oestrogenic effects are exerted mainly in brain, bone and vaginal tissues and are responsible for control of vasomotor symptoms and prevention of bone loss. The effect of the progestogenic metabolites on the endometrium prevents hyperplasia. Limited conversion of oestrone to oestradiol may reduce the oestrogenic effects of tibolone in the breast. Androgenic effects are thought to enhance testosterone availability by reducing sex hormone binding globulin (SHBG).