Vitamin D Supplementation prevents SARS-CoV-2 infection without serious Adverse Events

Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial

Objective

To determine the efficacy and safety of VD-supplementation in the prevention of SARS-CoV-2 infection in highly exposed indiv

Results

Of 321 recruited subjects, 94 VDG and 98 PG completed follow-up. SARS-CoV-2 infection rate was lower in VDG than in PG (6.4 vs. 24.5%, p <0.001). The risk of acquiring SARS-CoV-2 infection was lower in the VDG than in the PG (RR: 0.23; 95% CI: 0.09–0.55) and was associated with an increment in serum levels of 25-hydroxyvitamin D3 (RR: 0.87; 95% CI: 0.82–0.93), independently of VD deficiency. No significant adverse events were identified.

Conclusions:

Our results suggest that VD-supplementation in highly exposed individuals prevents SARS-CoV-2 infection without serious AEs and regardless of VD status.
https://www.sciencedirect.com/science/article/pii/S0188440922000455

Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial

https://www.sciencedirect.com/science/article/pii/S0188440922000455

Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease https://pubmed.ncbi.nlm.nih.gov/33512007/