Reversing Your BioAge: Longevity News & Updates | Ryan Smith @TruDiagnostic

The longevity/anti-aging industry changes rapidly. To share some of the latest and greatest, I brought on Ryan Smith. He, and the entire team at @TruDiagnostic, are building the infrastructure to determine what supplements, drugs, and health interventions actually work to slow biological aging.

📕  Video chapters
0:00 Introduction
0:35 Ryan Smith’s non-negotiable health, performance, and bioharmony routines
1:58 How Ryan evaluates longevity protocols
3:07 Summary of biological aging from MBPP Episode 47
4:42 What is epigenetics and its relation to biological aging
6:50 What is aging and how it is measured
9:53 What is hazard ratio
10:55 Why TruDiagnostic focused on epigenetic methylation instead of other forms of biological age testing
13:38 Difference of 1st, 2nd and 3rd generation biological aging clocks
17:33 What is the imprintome and the human imprint project
19:53 Study of mice exposed to BPA and/or vitamins
21:54 Mark Woolen’s book “It Didn't Start with You” and inherited trauma
23:40 Study done by Trudiagnostic and North Carolina State to decode the human imprintome
24:25 How to avoid passing trauma down through generations
26:33 How being exposed to certain things changes imprintome regions
28:44 Measuring your biological age via epigenetics is safe
29:57 Importance of twins in epigenetic research
31:36 What’s new in longevity and biological age testing
32:20 What is the Human Genome Project
34:00 What are multiomic clocks
34:50 Impact of the immune system on epigenetic age
37:46 How to change our biological age and overall bodily performance
38:15 Basic things to implement to slow biological age
40:15 Nick Urban’s approach to improving overall performance
40:55 Health and stress management effects on longevity
42:22 Highest impact areas of focus to make your health and performance easier
43:16 Ryan’s perspective on popular anti-aging therapies
43:54 Methylene Blue
44:18 Antioxidants such as melatonin, glutathione, superoxide dismutase, and chlorophyll
44:52 Senolytic agents
46:44 Pterostilbene
47:16 Spermidine
47:34 Astaxanthin
47:56 Vitamin C
48:27 Blood sugar regulators, metformin, berberine, the rock lotus, certain vitamins and minerals
49:36 Natural sunlight
51:03 Red light therapy
51:23 Filtering water
51:50 Green spaces and other essential lifestyle habits
52:45 Ryan’s stance on NAD precursors, NMN, MIB-626
54:30 Small molecules Ryan’s used for performance
55:15 Nootropics and supplements for cognitive performance
56:22 Semax
57:03 Dihexa
59:55 Tesofensine
61:12 Connect with Ryan Smith and TruDiagnostic
61:35 Use code "URBAN" for a deal on TruDiagnostic’s tests
62:03 Ryan’s top teachers
62:42 Latest research interest
62:54 Something Ryan's changed his mind on
63:21 Ryan’s favorite gift under $500
64:51 Final thoughts

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📝 About our guest
Ryan Smith graduated with Biochemistry at Transylvania University. After finishing his studies he created Tailor Made Compounding to synthesize peptides and formulations for pharmaceutical preparations. It became the 4th fastest-growing company in healthcare. In late 2020, he closed Tailor Made Compounding to focus on biological age research and testing at his new venture called TruDiagnostic. TruDiagnostic is a major player in longevity research, with over 30 approved clinical research studies investigating how longevity and health interventions impact epigenetic methylation.

🔑 Key takeaways
- The generations after you could inherit your traumas.
- You can slow down epigenetic aging via stress management
- Exposure to specific substances can alter particular imprintome regions.

🔗 Links
- Full episode show notes: https://mindbodypeak.com/82
- Music by Luke Hall: soundcloud.com/c_luke_hall

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