New Research: Green Tea & What Other Longevity Compound Reduces Alzheimer's Plaques?

A study out of Tufts University has shown that a combination of green tea and other compounds can prevent the formation of amyloid plaques.
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Alzheimer's disease is the 6th leading cause of death in the United States.
• It affects more than 6 million Americans, and its incidence is expected to rise significantly in the coming decades.
• And I would assume that these figures are very similar in most first and second world countries.
The cause of Alzheimer's disease, in its most common form, which is not genetically based, is not understood that well.
• Not knowing the cause makes treatment very difficult, but progress is being made.
• Earlier this year, using a 3D model of living human brain cells, Tufts University researchers showed that the common herpes virus could induce plaques in the brain associated with Alzheimer's disease.
Those Tufts researchers are now working to understand what might help to slow the progression of the disease.
• To date, they have tested 21 different compounds in Alzheimer's-afflicted neural cells in their Lab; they are measuring the compounds' effect on the growth of sticky beta amyloid plaques.
These are the plaques that develop in the brains of people who have Alzheimer's disease.
The researchers found that two of the 21 common compounds they tested reduced the formation of plaques in those neural cells.
The two compounds were green tea catechins; Catechin is a flavanol, a type of secondary metabolite that provides antioxidant properties in plants. It belongs to the subgroup of polyphenols called flavonoids.
The second compound was resveratrol; known I’m sure to many who follow the work of Dr. David Sinclair, resveratrol is found in red wine and some other foods, it can also be extracted from grape skins and turned into a supplement - in the form of a powder.
Some of the 21 compounds tested reduced the disease progression by acting as anti-viral agents - slowing the Alzheimer's induced by the herpes virus.
Dana Cairns PhD, of the Kaplan Lab in Tufts University said “Finding a compound that could diminish the plaques regardless of the virus component would be ideal, because that would show that regardless of the cause of Alzheimer's, you might still see some kind of improvement."
The initial screening was done in simpler models; the compounds that had a positive effect were tested in the 3D neural tissue model.
• That model is created using a non-reactive silk sponge seeded with human skin cells that, through genetic reprogramming, are converted into neural stem cell precursors.
• “Those cells grow and populate the sponge, which allows for 3D network formation of neurons similar to what you'd see in the human brain." explained Dr. Cairns.
Dr. Cairns explained that “The initial screen found five compounds had really robust prevention of these plaques. In addition to the green tea compounds and resveratrol, they found curcumin from turmeric, the diabetic medication Metformin, and a compound called citicoline prevented plaques from forming and did not have anti-viral effects.”
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