Endocrinologist Forecasts More Hormone-Related Diseases

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Dr. Flavio Cadegiani, a Brazilian endocrinologist, suspects that the worst has yet to come for spike protein-induced diseases in the endocrine system.

The endocrine system, colloquially known as the hormone system, is critical for our health. It regulates growth and development, mood, metabolism, reproduction, immunity, and functions of other organs through the secretion of hormones.

Hormones are one of the three biggest messengers in the body. Compared to the two other messengers—neurotransmitters and cytokines—hormones are slower in responding, and have systemic functions across the body rather than localized actions.

While cells can usually respond to neurotransmitters in milliseconds and cytokines in minutes to hours, cells that respond to hormones can take hours or even weeks.

Since hormones can have slow and systemic actions, a dysfunctional or damaged endocrine system will generally be slow in its symptom onset and recovery.

Studies have shown that spike proteins from COVID-19 infection and the vaccines can damage endocrine glands, including pituitary, thyroid, and adrenal glands, as well as reproductive organs, and many more.

Cadegiani raised a concern that the slower onset of endocrine pathologies may pose difficulties in diagnosis and treatment.

Depletion of Hormonal Reserves
Endocrine pathologies can take longer to become apparent because endocrine glands have “reserves,” according to Cadegiani.

“What we’re going to see in the future [for endocrine diseases] is a little bit different from the other fields, because glands have reserves and the decrease of the reserve will not be clinically seen right now, but it may be in the future,” said Cadegiani at a Front Line COVID-19 Critical Care Alliance (FLCCC) conference in Kissimmee, Florida.

Therefore, affected individuals may show no symptoms until their reserves have been depleted.

Cadegiani said that most of his concerns for the future are speculative and based his own clinical observations. But since the pandemic and the administration of COVID-19 vaccines began, there have been increasing reports that implicate endocrine pathologies.

Hormones regulate the entire body, so once the reserved are depleted and underlying endocrine pathologies are unmasked, there may be cases of systemic dysregulations.

Endocrine glands control the function of many organs across the body, and each endocrine organ is also connected through a feedback loop, also known as a hormonal axis.

At the top of this chain is the hypothalamus, which is a diamond structure in the brain and acts as a master switchboard. It sends messages to the pituitary glands, a small, oval structure tucked behind the nose.

The pituitary gland is colloquially known as the master gland; it regulates other endocrine organs, together with the hypothalamus forming hormonal axes.

The pituitary gland is part of the hypothalamic-pituitary-gonadal (HPG) axis which regulates the reproductive organs including the ovaries and the testes. In females, it is responsible for regulating the release of ovarian hormones as part of the menstrual cycle, and in males the axis regulates spermatogenesis.

The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine axis that mediates the adrenal glands, an organ that produce hormones that trigger the fight or flight response. The fight or flight process is a stress response that occurs in response to harmful threats, and can reduce metabolism, suppress immune, as well as activate the sympathetic nervous system.

Another major axis is the hypothalamic-pituitary-thyroid (HPT) axis. This regulates the thyroids and the hormones it secretes. Thyroid hormones are essential for biological functions of growth, regulation of the cardiovascular system, bone replacement, liver function, and metabolism.

The spike protein is the most toxic part of the SARS-CoV-2 virus. Studies on people with long COVID and post-vaccine symptoms often detected spike protein presence months or even a year after the exposure.

Spike protein particularly favors tissues and organs that express ACE2 and CD147 receptors. Many endocrine glands display ACE2 receptors, including the pancreas, thyroid, testes, ovaries, adrenal glands, and the pituitary gland, making the endocrine system particularly vulnerable to SARS-CoV-2.

The key driver behind spike protein-induced disease is inflammation.

Upon entering cells, spike protein can activate pro-inflammatory pathways by inducing DNA damage, inhibiting DNA repair, causing stress to the cell’s mitochondria, which is critical for cell energy production, and many more.

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