New Research: Nicotinamide Riboside (NR) Risk of Cancer | Brain Metastasis

A new, slightly worrying study out of the University of Missouri has looked into a link between Nicotinamide Riboside (NR) as a dietary supplement and the spread of existing cancer to the brain.
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Links:

https://www.sciencedirect.com/science/article/abs/pii/S0956566322008661?via%3Dihub
https://pubmed.ncbi.nlm.nih.gov/14713107/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352172/
https://www.reddit.com/r/Nootropics/comments/ysrmn9/a_bioluminescentbased_probe_for_in_vivo/

Elena Goun PhD, an Associate Professor of Chemistry at the University of Missouri said "Some people take them [them being vitamins and supplements] because they automatically assume that vitamins and supplements only have positive health benefits, but very little is known about how they actually work. Because of this lack of knowledge, we were inspired to study the basic questions surrounding how vitamins and supplements work in the body."
An international team of researchers led by Elena Goun, an associate professor of chemistry at the University of Missouri, discovered that high levels of Nicotinamide Riboside (NR) could not only increase someone's risk of developing triple-negative breast cancer, but also could cause the cancer to metastasize or spread to the brain.
Once the cancer reaches the brain, the results are deadly because no viable treatment options exist at this time, said Professor Goun, who is also the corresponding author on the study.
Increased cellular energy
• Following the death of her 59-year-old father only three months after being diagnosed with colon cancer, Professor Goun was moved to pursue a better scientific understanding - specifically around - cancer metabolism, or the energy through which a cancer spreads throughout the body.
• Since NR is a known supplement for helping increase levels of cellular energy, and cancer cells feed off of that energy with their increased metabolism, Goun wanted to investigate (Nicotinamide Riboside) NR's role in the development and spread of cancer.
Elena Goun PhD said "Our work is especially important given the wide commercial availability and a large number of ongoing human clinical trials where NR is used to mitigate the side effects of cancer therapy in patients."
The researchers used cutting edge technology to compare and examine what NR levels were present in cancer cells, T cells and healthy tissues.
"While NR is already being widely used in people and is being investigated in so many ongoing clinical trials for additional applications, much of how NR works is a black box - it's not understood. So that inspired us to come up with this novel imaging technique based on ultrasensitive bioluminescent imaging that allows quantification of NR levels in real time in a non-invasive manner. The presence of NR is shown with light, and the brighter the light is, the more (Nicotinamide Riboside) NR is present."
Professor Goun explained that the findings of the study emphasize the importance of carefully investigating the potential side effects of supplements like Nicotinamide Riboside prior to their use in people who may have different types of health conditions.
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