Chronic Inflammation - Pathogen Elimination and Important Inflammatory Cytokines

Long Story Short with Dr. Been
Episode 10: Chronic Inflammation - Pathogen Elimination and Important Inflammatory Cytokines (Lecture 2)

In this talk we will discuss how the inflammatory process is executed to contain microbes, repair tissue damage and to remove microbes, damaged tissue cells, worn out cells and irritants.

We will look at:
• Sentinel cells (mast cells, macrophages, neutrophils) and how these cells sense and ingest the microbes, damaged cells, or irritants and then destroy them
• Important cytokines and chemokines, especially TNF, IL-1 and IL-6
• The process of respiratory burst or reactive oxygen species production in neutrophils
• Reactive nitric oxide species in macrophages
• Proteolytic enzymes

The point of the above topics is to bring to light the mechanisms which, when dysregulated, play at the core of chronic inflammation. We will then discuss how various therapies target and modulate these mechanisms.

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References: 

Textbook: Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 94). Elsevier Health Sciences. Kindle Edition. 

URL list from Wednesday, May 25, 2022 

Chronic Inflammation - StatPearls - NCBI Bookshelf https://www.ncbi.nlm.nih.gov/books/NBK493173/ 

Inflammation - Wikipedia https://en.wikipedia.org/wiki/Inflammation 

Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753746/ 

Frontiers | Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals | Immunology https://www.frontiersin.org/articles/10.3389/fimmu.2018.01523/full 
Role of nitric oxide in inflammatory diseases 

https://pubmed.ncbi.nlm.nih.gov/18236016/#:~:text=Nitric%20oxide%20(NO)%20is%20a,over%20production%20in%20abnormal%20situations. 

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Disclaimer: 
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. 
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