Metformin anti-aging effect

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Metformin is an F-D-A-approved first-line agent for the treatment of type 2 diabetes. It has been shown to prevent diabetes to individuals with a high risk of developing complications. In addition to its hypoglycemic effect, metformin has demonstrated beneficial effects in age-related diseases. In a study, metformin has been shown to reduce the incidence of cardiovascular events in overweight patients with type 2 diabetes compared to patients treated with insulin. Numerous studies have indicated that metformin can delay the aging process by modulating aging-related pathways. Aging is regulated by a variety of mechanisms, including nutritional sensing pathways, reactive oxygen species-regulated stress, protein homeostasis, telomeres, and epigenetics. Modification in the signaling activities of these pathways can accelerate or slow the aging process. Metformin delays aging through various mechanisms like regulating insulin and insulin-like growth factor signaling. Elevated insulin increases age-dependent insulin resistance, which results in accelerated aging. Therefore, treatment with metformin enhances insulin sensitivity and lifespan. Moreover, metformin reduces the accumulation of advanced glycation end products or AGEs, which is a critical marker of aging, defined as glycated proteins as a result of exposure to sugars. Increased exposure to sugars causes alterations of biological functions to proteins, transforming them into aging proteins. AGEs are not only biomarkers of aging but also implicated in the development of many age-related diseases such as diabetes, atherosclerosis, chronic kidney disease, and Alzheimer's disease. By facilitating glucose utilization in the tissue, metformin reduces the accumulation of AGEs delaying the progression of aging and age-related diseases. During its 60 years of clinical application, metformin provides unparalleled advantages for providing various health benefits such as cardiovascular protection, anticancer and anti-inflammatory properties. It's important to talk to your doctor or other professional before beginning any sort of supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Topic related to: METFORMIN, LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, Metformin.

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