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Urolithin A - anti-aging benefits
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Urolithin A is a natural compound, produced endogenously by human gut microflora. The precursors of Urolithin A are polyphenolic compounds that contain ellagic acid and ellagitannins found in nuts and fruits such as pomegranates, raspberries, muscat grapes and strawberries.
Not everyone has a microbioma capable of producing urolithin A, only 40% of people can naturally
convert polyphenols to meaningful level of Urolithin A, which is why it is highly beneficial taking Urolithin A supplementation.
Moreover, the amount of urolithin A produced from polyphenols in the body seems to be insufficient
to achieve adequate levels of urolithins in the body.
There are numerous studies that have proven the important role of this compound in improving cardiovascular function by inhibiting enzymes like lipase or glucosidase and relieving insulin
resistance.
Urolithin A may also have an important role in the prevention of certain cancers, such as colorectal or prostate cancers.
The anticancer effects of Urolithin A are thought to be achieved through the regulation
of oncogenes, which are mutated genes that potentially cause the development of cancer.
A study in 2020 has shown the potential neuroprotective effect of Urolithin A in neuroblastoma cell
line derived from mice against ischemic neuronal injury by activating autophagy.
At the cellular level, Urolithin A increases mitophagy both in vitro and in vivo.
Mitophagy is a cellular process in which damaged and unwanted mitochondria are selectively removed from the cell, thus promoting the generation of new and healthy mitochondria.
Mitophagy takes place when mitochondria are damaged or when exposed to mitophagy inducers.
Mitochondrial dysfunction is one of the hallmarks of aging. Dysfunctional mitochondria are degraded through mitophagy, however, during aging chronic oxidative stress can accumulate and can induce dysregulation of mitophagy. Increased mitochondrial damage accelerates the aging process, either in physiological aging or in pathological age-related conditions. It's important to talk to your doctor or other professional before beginning any sort of supplementation or treatments.
Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, Urolithin A.
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