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Boswellia serrata
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Boswellia serrata is a medicinal tree that grows in dry mountainous regions of India, Northern Africa and Middle East. Gum-resin extracted from this tree has been used in tradional medicine for thousands of years to treat various chronic diseases. In traditional Ayurvedic medicine, the gummy resins of Boswellia serrata have been used as a remedy for diarrhoea, dysentery, syphilitic diseases and bronchitis. Gum-resin extracts of Boswellia serrata monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids that are responsible for inhibition of pro inflammatory enzymes. One of these gum-resin extracts include beta boswellic acid which have been demonstrated to inhibit hypersensitivity reactions by regulating both the humoral and cellular immune systems. In vitro studies have demonstrated that boswellic acids inhibit the synthesis of pro inflammatory enzymes including 5- lipoxygenases and leukotriene B4, which cause bronchoconstriction, chemotaxis, and increased vascular permeability. One novel gum resin extract is insensole acetate which inhibits nuclear factor kappa B activation, which has been demonstrated to play a key role in the onset and progression of many chronic diseases.
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