Why women are more likely to develop Alzheimer's disease (estrogen and Alzheimer's disease)

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Alzheimer's disease is the most common cause of dementia that affects over 24 million patients worldwide, according to the Alzheimer's Association, 2021. One of the major risk factors for developing late-onset Alzheimer's disease is female sex, regardless of age and ethnicity. However, the underlying reason remains unkniwn. According to one hypothesis, low estrogen levels is associated with Alzheimer's disease development. Recent evidence suggests that estrogen has neuroprotective effects. A study published in BMC Neuroscience Journal in 2006 has demonstrated that 17 beta estradiol, a potent type of estrogen, prevents mitochondrial failure and resultant appoptosis in hippocampal neuronal cultures. Damaged mitochondria leads to an a reduction in cerebral metabolic rate, in which neurons aren't able to receive adequate amount of energy for them to maintain their function. The study also has demonstrated that it maintains calcium homeostasis. According to a calcium hypothesis of Azheimer's disease, dysregulation in calcium homeostasis. Free intercellular calcium acts a messenger in many signalling pathways of neurons, and alterations in intracellular calcium homeostasis are involved in brain aging, memory, and cell death.
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