Ursolic acid

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Ursolic acid
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Ursolic acid is a natural triterpene compound that are found in various plant sources. Ursolic acid has been shown to have pharmacological effects including anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects. These effects are due to its ability to suppress nuclear factor-kappa B factor. Nuclear factor-kappa B is a central mediator of pro-inflammatory gene functions in immune cells. Nuclear factor-kappa B is an ubiquitous transcription factor that regulates a series of genes involved in many diseases associated with inflammation and immune system such as atherosclerosis, muscular dystrophy, stroke, and viral infections. In the brain. ursolic acid has been shown to play a protective role in various brain diseases caused by oxidative stress and excitotoxicity. Moreover, ursolic acid has been evidenced to suppress apoptotic signaling protecting the brain from ischemic stroke. Due to its ability to attenuate inflammation and oxidative stress, ursolic acid has been reported to prevent the depletion of glutathione in the hippocampus. It also has been reported to suppress the upregulation of interleukin 1 beta, interleukin 6, and tumor necrosis alpha factor levels in the hippocampus in mice. The amelioration of oxidative stress and inflammatory response in the hippocampus may offer a novel therapeutic strategy in treating Alzheimer's disease.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, LONGEVITY PROTOCOL.

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