Dr. Jennifer Ashton warns boosters may lead to harmful immune tolerance (May 2022)

"If you already have high antibody levels and you get another booster, your immune system may say, 'What am I needed for?' and start to shut down."

Dr. Jennifer Ashton mentions a recently published study which shows, unsurprisingly, that antibody levels surge in the weeks after injection. No reference was provided, but it may be this article:

Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(22)00271-7/fulltext

There are a number of important caveats to this finding:

First, we don't know how long this lasts. (But judging from data that are available and looking at the trend, it's probably a few weeks at most.)

Second, antibody levels are NOT the same as protection. T-cells (and many other parts of the immune system) also play a more important role, but they are much harder to measure than antibodies.

Third, it matters enormously whether the antibodies are neutralizing. If they're not neutralizing, for instance because they are for the wrong variant, they may be ineffective at best or harmful at worst. In the latter case, they may act like a Trojan horse in a phenomenon called Antibody-Dependent Enhancement (ADE), which was the reason that all previous coronavirus vaccines failed. They will usher a pathogen in instead of neutralizing it, thus leaving the vaccinated person at elevated instead of reduced risk. With antibodies, quality is much more important the quantity.

Fourth, there is the risk of immune tolerance where the immune system quits responding to an antigen. This is desirable in the case of allergies, for example with hay fever and pollen. However, if it happens with infections, it's very, very bad. It will lead to a higher chance of (re-)infection, longer and more severe sickness, increased chance of death, longer and more infectiousness, and possibly the quicker emergence of variants.

Not mentioned by dr. Aniston, but still relevant, is the risk of immune exhaustion.

Read this article for more information about immune tolerance:

Boosters Now PROMOTE Covid Deaths in Europe | Igor Chudov
https://igorchudov.substack.com/p/boosters-now-promote-covid-deaths

A GOOD YOUTUBE COMMENT

The third dose increases immunity, so after the fourth dose you'll be protected. Once 80% of the population has received the fifth dose, the restrictions can be relaxed as the sixth dose stops the virus from spreading.

I am confident that the seventh dose will solve our problems and we'll have no reason to fear the eighth dose. The clinical phase of the ninth dose will confirm that the antibodies remain stable after the tenth dose. The eleventh dose will insure that no new mutations will develop, so there is no longer any reason to criticize the twelfth dose.

SEE ALSO

European Medicines Agency (EMA) warns repeated booster shots could cause immune response problems
https://rumble.com/vsj4mn-european-medicines-agency-ema-warns-repeated-booster-shots-could-cause-immu.html

SOURCE: https://www.youtube.com/watch?v=LXDH-xKIk0A