DOM D’AGOSTINO 3a | WARBURG EFFECT: Cancer is metabolic disease…Feeds only on glucose

http://www.DoctorsToTrust.com
presents episode 463 | Dr Dom D’Agostino
IHMC podcast

In research on hyperbolic oxygen, what happens to cells of various types?
-high oxygen is toxic to cancer cells!
-causes an overproduction of oxygen free radicals, which
-overwhelms the antioxidant
capacity of the cells,
-they die
-cancer cells were more
vulnerable to levels of oxygen
that were not lethal to
normal cells

Also found that ketones are toxic to cancer cells...
-but normal brain cells, given ketones, grow perfectly
-even when no glucose, brain cells thrive
Cancer cells:
-take away glucose;
-give them ketones:
-they die

Our healthy cells have a very high degree of metabolic flexibility...
-can burn either glucose (carbs) or ketones (fat)

Cancer cells lack metabolic flexibility...
-due to damage to their mitochondria
-they cannot switch over from glucose as a fuel
Tumor growth tightly
correlated with glucose
-at low levels of glucose...
-very little tumor growth!

Fluoro-deoxy-glucose PET scan...
-here, this person has metastatic cancer
-in lung, liver, bone: cancer cells are OUTCOMPETING healthy cells
-for glucose
PET scans are gold
standard to track cancer:
-diagnosis
-locations
-track aggressive growth

Otto H Warburg, 1931 Nobel Prize for
-his research on cancer
-showed that cancer cell mitochondria
had defects that caused them to
only burn glucose for energy!
-described it as a metabolic disease

ALL CANCER
CELLS HAVE
DYSFUNCTIONAL
MITOCHONDRIA
-genetic defects
DIFFER across
cancer tumors
-even within the
same tumor!
-BUT ALL CANCERS
HAVE SAME
METABOLIC
PHENOTYPE!

ALL CANCER
CELLS HAVE
DYSFUNCTIONAL
MITOCHONDRIA
-GLUCOSE
OVER-
CONSUMPTION
-due to
mitochondrial
dysfunction

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Original Youtube: https://youtu.be/gONeCxtyH18
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