Premium Only Content

RepA-WH1 Prionoid
RepA-WH1, the agent of an amyloid proteinopathy in bacteria, builds oligomeric pores through lipid vesicles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794723/
What is EGCG? Green Tea
Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives
https://pubmed.ncbi.nlm.nih.gov/16876833/
RepA-WH1 in the news 30 June 2020
SynBio and the Boundaries between Functional and Pathogenic RepA-WH1 Bacterial Amyloids
To fulfill the current expectations on the use of amyloid nanomaterials in SynBio applications, achieving control of amyloid nucleation and growth and of any potential cytotoxic side effects is an essential goal. As addressed here, ligand-promoted amyloidogenesis can provide such fine-tuned levels of regulation and thus should be explored further. Conversely, engineering amyloid cytotoxicity in bacteria, coupled to horizontal gene transfer, might enable new ways to selectively eliminate either bacterial pathogens or specific bacteria from an engineered microbial consortia to program changes in strain composition in biotechnological processes, as proposed for light-modulated cell ablation by “optobiotics” (63). It might be interesting to test synthetic bacterial prion-like proteins, as generated by engineered microbiota, in the current animal models of human amyloidoses to assess their possible effect on disease onset and progression. Small bacterium-related mobile genetic elements encoding just a protein carrying a domain like RepA-WH1 have been isolated from bovine meat and dairies, and also from primary human tumors while the patients developed antibodies against the protein (80). So probably, there is still plenty of room to be explored for bacterial amyloids in human diseases.
https://journals.asm.org/doi/full/10.1128/mSystems.00553-20
SYNTHETIC BACTERIAL AMYLOIDS
https://www.cnb.csic.es/index.php/en/investigacion/departamentos-de-investigacion/biotecnologia-microbiana/amiloides-bacterianos-sinteticos
-
Epstein Borreliosis AIDS
2 years agoOPERATION WARPED SPEEDILY ROLLING OUT THE GREAT RESET OF HUMANITY AND THE BIOSPHERE
3722 -
2:39:23
TimcastIRL
6 hours agoTrump Admin Accidentally Leaked War Plans To Liberal Journalist, But It May Be HOAX | Timcast IRL
232K78 -
2:05:10
Glenn Greenwald
9 hours agoAtlantic Leak Reveals Trump Admin's Foreign Policy Mindset; Appeals Court Extremely Skeptical of Trump's El Salvador Deportation Powers; Israel's Horrific Crimes in the Last 24 Hours | SYSTEM UPDATE #428
141K160 -
1:53:20
megimu32
7 hours agoON THE SUBJECT: The Soundtracks That Raised Us – Iconic Movie Music from the 80s, 90s & Y2K
63K11 -
3:01:26
Danny Polishchuk
11 hours agoEpstein Files + Government Group Chat Leaked with Guest Nick Bryant | Low Value Mail
46.2K5 -
52:47
BonginoReport
9 hours agoDems Are LOST and The Biggest Losers Are Here To Help! (Ep. 11) - Nightly Scroll - 03/24/25
188K142 -
53:58
Sarah Westall
7 hours ago“Millions and Millions have Died” Hidden Crimes of Big Pharma & Johnson & Johnson w/ Gardiner Harris
71.7K29 -
1:40:49
Redacted News
10 hours agoSomething BIG is coming on April 2nd as Trump plans "Liberation Day in America" | Redacted News
270K323 -
1:11:34
Kim Iversen
11 hours agoOops! Vance and Hegseth Accidentally Leak War Plans on Signal | Big WIN For Medical Freedom Movement
106K168 -
1:06:30
TheSaltyCracker
10 hours agoSaltcast Stream 03-24-25
148K179