Health

A simple yet safe treatment and management. For doctors and health workers, highlighting cases and amazing results. With Dr. Shankara Chetty, Dr. Allan Landrito and Dr. Mahin Khatami. Support information and further reading: A message to the medical community from A. M. Gonzalez
https://doorlesscarp953.substack.com/p/a-prostate-community-trial Ivermectin, a potential anticancer drug derived from an antiparasitic drug (2021) "In healthy volunteers, the dose was increased to 2 mg/Kg, and no serious adverse reactions were found, while tests in animals such as mice, rats, and rabbits found that the median lethal dose (LD50) of IVM was 10-50 mg/Kg"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/ Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175311/#__ffn_sectitle The effect of fasting or calorie restriction on autophagy induction: A review of the literature (2018)
https://www.sciencedirect.com/science/article/pii/S1568163718301478?via%3Dihub Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer (2021)
https://www.nature.com/articles/s41523-021-00229-5 Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress (2018)
https://pubmed.ncbi.nlm.nih.gov/29428725 "Helicases are a class of enzymes thought to be vital to all organisms. Their main function is to unpack an organism's genetic material. Helicases are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating two hybridized nucleic acid strands (hence helic- + -ase)"
https://en.wikipedia.org/wiki/Helicase Targeting SARS-CoV-2 non-structural protein 13 via helicase-inhibitor-repurposing and non-structural protein 16 through pharmacophore-based screening (2022) "...In our analysis, ivermectin, scutellarein and myricetin showcases the highest binding affinity among the selected inhibitors with binding affinity of −10, −9.9 and −9.7 kcal/mol, respectively, (Table 2). Among the nineteen compounds, seven chemical entities had binding affinihes greater than or equal to −9 kcal/mol. These chemicals are ivermectin, scutellarein, myricelin, suramin, nogalamycin, doxorubrun and paclitaxel as shown by Table 2"
https://link.springer.com/article/10.1007/s11030-022-10468-8 Development of a miRNA-controlled dual-sensing system and its application for targeting miR-21 signaling in tumorigenesis (2020) "...Importantly, molecular modeling-based screening confirmed the action of the miR-21-targeting drug ivermectin and led to the identification of a new effective derivative, GW4064, for inhibiting oncogenic DDX23-miR-21 signaling."
https://www.nature.com/articles/s12276-020-00537-z Caution is warranted against taking NAC long term if you are a cancer patient as it may stop existing drugs from working as it protects the nucleus from cytotoxic substances: N-acetylcysteine enhances multidrug resistance-associated protein 1 mediated doxorubicin resistance
https://pubmed.ncbi.nlm.nih.gov/15473893/ Diphenhydramine and Lactoferrin: Scientist surprised by discovery of '99%' effective, cheap COVID treatment? (2022)
https://covid19.onedaymd.com/2022/01/diphenhydramine-and-lactoferrin.html "Metastatic cancer can induce systemic glycolysis as part of the Warburg Effect and the Kynurenine Pathway, which is immunosuppressive, affects the gut biome negatively and is pro-tumor"
https://doorlesscarp953.substack.com/p/spike-protein-inc-vax-induced-immunodeficiency-d03 Therapeutics and repurposed drugs for the treatment of cancer
Selected research papers reviewed
https://doorlesscarp953.substack.com/p/therapeutics-and-repurposed-drugs Therapeutics for Supporting Immunity & Long Covid
https://doorlesscarp953.substack.com/p/therapeutics-for-long-covid Therapeutic Properties of Baicalin - A Literature Review
https://osf.io/2w8yn