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Accidentally on purpose https://dictionary.cambridge.org/dictionary/english/accidentally-on-purpose WEF prepares for Disease X https://www.weforum.org/events/world-economic-forum-annual-meeting-2024/sessions/preparing-for-a-disease-x/?utm_source=substack&utm_medium=email Laboratory-acquired infections and pathogen escapes worldwide between 2000 and 2021 https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00319-1/fulltext Laboratory-acquired infections (LAIs), and accidental pathogen escape from laboratory settings (APELS), are major concerns for the community. A risk-based approach for pathogen research management, within a standard biosafety management framework is recommended, but is challenging. due to reasons such as inconsistency, in risk tolerance and perception. Here, we performed a scoping review, using publicly available, peer-reviewed journal and media reports, of LAIs and instances of APELS between 2000 and 2021. Laboratory-acquired infections (LAIs) 309 individuals, 94 reports for 51 pathogens. Eight fatalities 2·6% of all LAIs Neisseria meningitidis (n=3, 37·5%) Yersinia pestis (n=2, 25%) Salmonella enterica serotype Typhimurium (n=1, 12·5%) Ebola virus (n=1, 12·5%) Bovine spongiform encephalopathy (n=1, 12·5%) Accidental pathogen escape from laboratory settings (APELS) 16 APELS were reported Bacillus anthracis (anthrax) SARS-CoV Poliovirus Brucella spp (brucellosis zoonosis) Foot and mouth disease virus Influenza virus H5N1 Examples the discovery of historical variola virus ampoules in cold storage during a move of laboratories at the National Institutes of Health campus in Bethesda, MD, USA in July, 2014 the shipment of live anthrax cultures from US Department of Defense laboratories following incomplete inactivation Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2- related Pangolin Coronavirus GX_P2V(short_3UTR) https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1.full.pdf SARS-CoV-2-related pangolin coronavirus GX_P2V can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans https://www.biblegateway.com Then another horse came out, a fiery red one. Its rider was given power to take peace from the earth and to make people kill each other. To him was given a large sword. (Revelation chapter 6, v 4)

Lethal Infection of Human ACE2-Transgenic Mice Caused by SARS-CoV-2- related Pangolin Coronavirus GX_P2V(short_3UTR) 4th January 2024 https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1.full https://www.biorxiv.org/content/10.1101/2024.01.03.574008v1.full.pdf SARS-CoV-2-related pangolin coronavirus GX_P2V can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans, and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses. Dear Editor, Two SARS-CoV-2-related pangolin coronaviruses, GD/2019 and GX/2017, were identified prior to the COVID-19 outbreak. The respective isolates, were cultured in 2020 and 2017 the early passaged GX_P2V isolate was actually a cell culture-adapted mutant. We assessed its pathogenicity in hACE2 mice. We found that the GX_P2V clone can infect hACE2 mice, with high viral loads detected in both lung and brain tissues. This infection resulted in 100% mortality in the hACE2 mice. We surmise that the cause of death may be linked to the occurrence of late brain infection. All the mice that were infected with the live virus succumbed to the infection within 7-8 days post-inoculation, rendering a mortality rate of 100% 5 days post-infection decrease in body weight 7 days post-infection piloerection, hunched posture, and sluggish movements, and their eyes turned white. 8 hACE2 mice were infected 8 mice inoculated with inactivated virus 8 mice mock-infected Dissections on days 3 and 6 Quantitative analysis of viral RNA and titer. Significant amounts of viral RNA in the brain, lung, turbinate, eye, and trachea no or a low amount of viral RNA was detected in heart, liver, spleen, kidneys, tongue, stomach, and intestines. Lung samples High viral RNA loads on days 3 and 6 post-infection Viral antigens also detected Viral load in the lungs significantly decreased by day 6 Lungs showed minimal inflammation Brain samples Day 3 post-infection, viral RNA was detected in all infected mice, shrunken neurons visible in cerebral cortex Viral antigens also detected Day 6 post-infection, exceptionally high viral RNA loads (∼ 8.5 Log10[copies/mg]) in the brain samples from all infected mice, focal lymphocytic infiltration around the blood vessels. Severe brain infection during the later stages of infection may be the key cause of death in these mice. To the best of our knowledge, this is the first report showing that a SARS-CoV-2-related pangolin coronavirus can cause 100% mortality in hACE2 mice, suggesting a risk for GX_P2V to spill over into humans. Propensity of coronaviruses to undergo adaptive mutation during passage culture. ……. requires further investigation. It is possible that GX_P2V C7 has undergone a virulence-enhancing mutation. Justin Kinney, Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, U.S. “The research is still very dangerous, though,” “I am especially concerned that the paper does not say what biosafety level the work was performed at. Coronavirus research in China is often done at a biosafety level (BSL-2) that is inadequate for working with potential pandemic pathogens that might be transmitted by air. “Indeed, coronavirus research done at BSL-2 may have caused the COVID-19 pandemic. And by showing that the coronavirus has a surprisingly high pathogenicity, the work underscores the need for extreme caution when working with novel coronaviruses.” https://www.theepochtimes.com/health/chinese-scientists-reveal-experiments-with-virus-100-percent-fatal-to-mice-5560854?utm_source=healthnoe&src_src=healthnoe&utm_campaign=health-2024-01-11&src_cmp=health-2024-01-11&utm_medium=email&est=WbDdGa4Q6Iq698FpcqUs8Zg1gnKWQsOyvg6pqjrDjV5egMs753Fg8CTOlo2Dgu4ObrfZxQ%3D%3D Lihua Song did not respond to a request for comment on how the scientists ensured the experiments they performed were safe. Yigang Tong Trained in a Chinese military program and worked in military-run labs. He also co-authored a paper in 2023 with Zheng-Li Shi, who helps run the Wuhan Institute of Virology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9972989/ Justin Goodman, senior vice president, White Coat Waste Project, a U.S. nonprofit “dangerous and deadly tests on mice.” “This is why shipping US tax dollars to foreign adversaries’ unaccountable animal labs is a recipe for disaster and we’re working with lawmakers to stop it,”