Biodigital Convergence

Cause Before Symptom - With Your Host James Carner Proof: Canada mRNA Surveillance Biodigital Convergence: Biodivergence I saw a video today of my friend (Tie_Yahna) Tajana Truthseeker, whom I interviewed a few years ago. She was talking about how Canada admitted to using mRNA vaccines on their website to track viruses along with your cell phones. yet they just removed the website right after she posted it. It says Our website is undergoing maintenance over the coming weeks. Some sections and documents may be temporarily unavailable. Watch this video. They removed the website and placed it in a special place where you had to actually find it. It reads: It is spurring biodigital innovations such as nearly real-time biosurveillance of virus spread and mutations; virus tracking via smartphone; and messenger ribonucleic acid (mRNA) vaccine development at unprecedented speed. It literally says it. Proof beyond a shadow of a doubt that they are using smart phones, AI and mRNA to track biodigital convergence, which they say is the merging of biological systems and digital technologies, is challenging the way we understand ourselves and the world in which we live. The report focusing on using this information of who took the vaccine and who didn’t. Then they will use this data to determine food production. It reads, “In this report, we delve deeper into how biodigital convergence could reshape five areas: food, health, environment, security, and manufacturing. We examine sectors in their current form, how biodigital convergence is changing each sector, what might change these sectors in the future, outline critical uncertainties and future possibilities, as well as policy considerations.” Here are the three main issues: Full physical integration of biological and digital entities
 When digital technology is embedded in organisms, or biological components are incorporated into technologies. Examples include robots with biological brains, digital implants in humans, and neurological control systems in insects. Digital technologies can enhance the natural capabilities of living things. Coevolution of biological and digital technologies
 When advancements in one domain enable progress in another, and vice versa. Both digital technology and the natural world provide scaffolding for each other, furthering shared breakthroughs and a coevolution. Examples include new understanding of how brains work, inspiring the development of neural networks; and artificial intelligence (AI) finding patterns in gene sequences that build our understanding of what genes do. Cognitive shift of biological and digital systems
 An evolution of perspective, where we begin to normalize the convergence of the natural world and digital technology. We may see the two as an integrated new domain. Advances in our understanding of biological systems and in the creation of new digital capabilities such as AI enables the biodigital conceptual convergence. None of this would work without something being inside the body. I knew Bill Gates’ hardware and software were in it, but didn’t have any definitive proof. This phrase: It is spurring biodigital innovations such as nearly real-time biosurveillance of virus spread and mutations; virus tracking via smartphone; and messenger ribonucleic acid (mRNA) vaccine development at unprecedented speed. They added a semi-colon to the phrase as if the same sentence is a conjunction. Smart Phone and mRNA development is the same sentence. And to follow up with what they are using this data for is food, health, environment, security and manufacturing. Sounds to me like communism has taken root in Canada. 81.1% of all Canadians have taken at least one shot. That’s enough. Their website says: How is biodigital convergence changing food? That line is disturbing. Why change food? Why not keep it organic? Anyways, I am getting ahead of myself. Let’s go over this entire document. It is absolutely atrocious, obvious and a crime. Against our will. The COVID-19 pandemic is proving to be a powerful driver of change. It is spurring biodigital innovations such as nearly real-time biosurveillance of virus spread and mutations; virus tracking via smartphone; and messenger ribonucleic acid (mRNA) vaccine development at unprecedented speed. Biodigital convergence, the merging of biological systems and digital technologies, is challenging the way we understand ourselves and the world in which we live. Building on our first report, Exploring Biodigital Convergence, this report lays out some of the changes we might see as the biodigital convergence matures and gives rise to new realities. It explores the potential impact of biodigital convergence on sectors such as health, food and agriculture, the environment, manufacturing, and security. It could have implications across many policy areas: global trade, healthcare, the shift to a low-carbon economy, natural resource management, and many more. Policy Horizons Canada (Policy Horizons) does not provide policy recommendations or advice. Guided by its mandate, it explores what might happen in the future policy landscape, to help the Government of Canada develop future-oriented policy and programs, and to prepare for possible radical and disruptive change. We hope you will find this report insightful and thought-provoking. By reflecting on what might happen, we can support Canadians and decision makers in considering which futures we want and which ones we want to avoid. On behalf of Policy Horizons Canada, I would like to thank those who generously shared their time, knowledge, and thoughts with us. Kristel Van der Elst

Director General,
Policy Horizons Canada Biological and digital systems are coming together in profound ways, creating a new domain called the biodigital. Digital technology and living things are increasingly able to communicate with each other. We can embed digital technology into living organisms, and incorporate biological components into new technologies. Genetic modification of the natural world for climate change mitigation, environmental remediation, and biodiversity conservation may however raise ethical considerations. The contours of the coming biodigital era are becoming clearer. This report explores change drivers and how biodigital convergence could transform five economic sectors and areas of life. Food Health Environment Security Manufacturing It examines some of the changes we could see in each area, how we could experience significant disruption in the future, and what policy considerations might emerge. This report also discusses how the COVID-19 pandemic may be accelerating the transition to a biodigital world. Food Traditional agriculture relies on land, water, and a suitable climate. In the future, foods could be manufactured anywhere in labs and indoor vertical farms. This could fundamentally reshape the agricultural sector, international trade, and migration, as well as people’s relationships with land, animals, and food. Health Biodigital convergence could rapidly advance targeted treatments, and precision medicine based on genomic profiles—leading to improved and targeted preventive care as well as highly efficient treatments for disease. At the same time, biodigital convergence also gives rise to inclusivity and ethical considerations, among others. Environment Climate change, pollution, and biodiversity loss are widely recognized as urgent global issues. Today’s unsustainable production and consumption modes are endangering long-term socioeconomic wellbeing. Biodigital capabilities could increase our capacity to connect with and monitor the natural world. It could also expand our understanding of the interconnectedness of all living things. Genetic modification of the natural world for climate change mitigation, environmental remediation, and biodiversity conservation may however raise ethical considerations. Furthermore, there may be unintended consequences involved with the release of modified organisms in natural environments. Security Emerging biodigital innovations and capabilities are creating both new frontiers and possible concerns in the field of security and defence. With almost five billion people connected to the Internet, digital surveillance and data collection have substantially increased over the last decade. The rise of biodata may add a new layer of complexity in securing potentially valuable personal data. The access to more data may also facilitate criminal investigation and potentially create a more secure society. Manufacturing Manufacturing was historically based on factory workers who transformed natural resources initially extracted from mines, forests, and waters, or grown on farms. Differences in labour costs and the natural distribution of resources have influenced the shape of our far-reaching global supply chains. Biodigital convergence could transform the natural resource sector through new ways of making and obtaining raw materials and fuels, as well as new manufacturing techniques, potentially easing pressure on natural resources. More localized production and distribution of goods and fuels could reshore manufacturing and reshape trade, disrupting trade patterns and supply chains. The COVID-19 pandemic is acting as a driver of change, accelerating the transition to a biodigital world. It has increased the awareness of biology and its array of uses among people, governments, and industry. It reveals the risks of misinformation and the need for bioliteracy. It pushes biodefence capabilities and national self-sufficiency to the forefront of government agendas. And it has forced societies to re-evaluate the balance between biosecurity and personal freedoms. The speed of biodigital convergence in the coming years will depend not only on technological progress but social acceptance—and the pandemic has shown that unexpected events can trigger rapid shifts in what is widely seen as acceptable or desirable. In the future, we may not see digital technologies and biological systems as separate, but rather woven together, further normalizing the biodigital world that future generations may inherit. Introduction This report continues the work of our Exploring Biodigital Convergence1 scoping report, which explored how biological systems and digital technology are converging in ways that could change how we live, understand and make sense of our lives, evolve, and possible capabilities and characteristics of biodigital innovations. We identified three ways in which biodigital convergence is emerging: Full physical integration of biological and digital entities When digital technology is embedded in organisms, or biological components are incorporated into technologies. Examples include robots with biological brains, digital implants in humans, and neurological control systems in insects. Digital technologies can enhance the natural capabilities of living things. Coevolution of biological and digital technologies When advancements in one domain enable progress in another, and vice versa. Both digital technology and the natural world provide scaffolding for each other, furthering shared breakthroughs and a coevolution. Examples include new understanding of how brains work, inspiring the development of neural networks; and artificial intelligence (AI) finding patterns in gene sequences that build our understanding of what genes do. Cognitive shift of biological and digital systems An evolution of perspective, where we begin to normalize the convergence of the natural world and digital technology. We may see the two as an integrated new domain. Advances in our understanding of biological systems and in the creation of new digital capabilities such as AI enables the biodigital conceptual convergence. In this report, we delve deeper into how biodigital convergence could reshape five areas: food, health, environment, security, and manufacturing. We examine sectors in their current form, how biodigital convergence is changing each sector, what might change these sectors in the future, outline critical uncertainties and future possibilities, as well as policy considerations. During our work on this report, we lived through the first global emergency of the biodigital era. In the final section, we reflect on the COVID-19 pandemic as a significant accelerator for the biodigital revolution—increasing investment in research, raising public awareness of biological threats, shifting perceptions of what is socially possible, and putting public health at the centre of national governance. The contours of the coming biodigital era are slowly becoming clearer and the transition to that era will inevitably be disruptive. By thinking now about the possible trajectories of biodigital convergence, we hope to reduce risks, and harness possibilities for Canada and the world. Food Traditional agriculture relies on land, water, and a suitable climate. In the future, foods could be manufactured anywhere in labs and indoor vertical farms. This could fundamentally reshape the agricultural sector, international trade, and migration, as well as people’s relationships with land, animals, and food. As the world’s population grows2, demand for and trade3 in food are expected to rise. Many countries may face food security challenges brought on by climate change, as extreme weather events and diseases affect traditional agricultural production. Regional conflicts may also disrupt global food production and trade. Food systems also have environmental impacts—land use, deforestation, water pollution, and greenhouse gas emissions—while opaque supply chains4 raise the risk of food-borne illnesses5. How is biodigital convergence changing food? Biodigital innovations have the potential to modify how we produce food, integrate new types of food onto the market, and disrupt existing supply chains. What follows are some of the ways biodigital is changing how we produce, grow, manufacture, and understand human nutrition and food. Lab-grown food. Cellular agriculture creates bioidentical animal products—such as seafood, meat, and dairy—in a lab. This involves culturing animal cells in a bioreactor and growing them into fat and muscle tissue. Lab-grown meat and plant-based meat alternatives can also be three-dimensionally printed (3D-printed)6. Lab-grown beef burgers are approaching cost parity7 with traditional burgers, especially when meat cells are combined with plant protein. In 2020, the world’s first restaurant serving lab-grown meat8 opened in Tel Aviv9, and Kentucky Fried Chicken announced plans to sell 3D-printed nuggets10. Companies are working on lab-grown salmon11, tuna12, shrimp13, dairy products14, pet food15 and even human breast milk16—a potential alternative to infant formula. Scaling bioreactors remains the main technological challenge17, but Chinese18 and Israeli19 organizations are investing heavily. Individualized diets based on DNA profiling. Advances in nutrigenomics20—the study of relationships between genes, nutrition, and health—could allow people to make health, diet, and lifestyle choices based on their genetic profile. Start-ups are offering personalized dietary advice21 based on DNA, lifestyle information, and gut microbiome analysis. A restaurant in Tokyo is using analysis of customers’ saliva, urine, and feces to evaluate their nutritional requirements and 3D print biome-based bespoke sushi22. Nestlé23 is investing in microbiome research and AI that can create personalized care plans. People can buy vitamin pills tailored24 to their genome, and one day may 3D print these types of supplements at home. The decreasing25 cost of genome sequencing will make personalized diets and lifestyle choices more widely accessible. Precision and smart farming. A combination of technologies could influence or alter how agriculture industries function—and how and where we grow food. Agricultural productivity26 could become more precise with technology—from robots inspecting individual plants27, identifying pests and diseases28, or herding farm animals29, to data30-optimizing fertilizer inputs, to blockchain-enabled origin tracing31. Indoor vertical farms in which AI32 controls light and temperature can grow hundreds of times as much food per acre as traditional agriculture, while using far less water. Singapore has launched a campaign33 to produce 30% of its food supply by 2030 through lab-grown food and vertical farming34. Companies from the U.S. to China35 are exploring how Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology might customize crops to particular conditions and improve resilience36 against climate change impacts. What might change in food systems in the future? As the biodigital convergence advances and matures, it could reshape food systems in significant ways: Grow anything, anywhere, anytime. Agriculture has always depended on the availability of land mass, water, and specific climatic and geographic conditions. It is limited by the growing seasons and vulnerable to variables beyond a farmer’s control—from weather to pests and diseases. With new biodigital innovations, these constraints may no longer shape agricultural productivity in the future. Lab-grown meat technology37 could be located anywhere, as can vertical farming where artificial intelligence (AI) oversees38 gene-edited crops grown in precisely controlled environments. Nations pursue self-sufficiency. Trade could change as nations pursue food self-sufficiency. Food-importing countries may opt to produce more food39 within their own borders, rather than importing it from areas with good natural growing conditions, to reduce their vulnerability to trade disputes40 or supply disruptions. As more than 75%41 of agricultural land is used for livestock farming, low-yield lands could become stranded assets and be replaced by cellular agriculture alternatives. We could increasingly produce food on demand and near consumers, potentially in small-scale home bioreactors. This could substantially reduce the demand for food transportation or distribution. Diet merges into preventive healthcare. Better understanding of the human genome and biome may transform nutrition and influence healthcare, giving people increasingly detailed information to highly individualize their diets and maximize their health. Increasing the amount of genome and biome data that is being collected and studied could advance our understanding of the human body as an intricate system and could facilitate preventative medicine. A database of consumers’ genomes may become a competitive advantage for some firms. Food for thought Our connection with the environment. Biodigital convergence could profoundly change people’s relationship with land and animals. Over the centuries, conditions for agriculture shaped where people settled. Our growing ability to produce food independent of climatic conditions could shift what people value in land, as well as patterns of human settlement. Local food production technology opens up opportunities for remote communities to be self-sufficient, and produce traditional foods in new ways. More land could be rewilded, while growing fish in labs could allow the oceans to replenish. Affordable lab-grown meat could lead to a shift in attitudes towards the ethics of factory farming and in our relationships with animals more generally. It could change the role of culture and ceremony in food production and consumption—how we grow, harvest, connect with, and experience food. The experience of food transforms. Biodigital convergence could transform how we think of and associate with food. While lab-grown food currently aims to mimic foods familiar to us, it opens up possibilities to create entirely new kinds of edible products with new tastes, textures, and nutrients. People could make “programmable” foods to fit their own tastes and needs. Biodigital technologies could potentially allow people to biohack their own taste buds to alter which tastes they find pleasing, orient them towards healthy food, and create new food cultures. Critical uncertainties and future possibilities Various factors could affect the scale and nature of acceptance or rejection of biodigital innovations. The following outlines some possible uncertainties that may lead to different future scenarios. Societal acceptance: Will there be a societal consensus on adopting new technologies? Consumers may increasingly want to buy healthy42, environmentally friendly, ethically produced foods. Given that vertical farms need less land, water, and pesticides—and that lab-cultured meat does not involve the methane emissions of farmed animals, or the ethical or health issues associated with factory farming—could we see an uptake in new food production methods? Could negative early experiences of CRISPR-modified crops and cultured meat affect public acceptance? Will CRISPR plant editing be more or less publicly accepted43 than previous means of genetically modifying organisms? How might we benchmark ethical considerations and values alongside biodigital economic possibilities? Business ecosystem: How could existing players reshape their business models? How might related sectors evolve, and what new players could emerge? Will the existing big agricultural companies adapt and maintain their position? Or will new entrants from other sectors, like pharmaceuticals and big techs, overtake them? Could technology’s increased role enable a dominant position for large tech companies in the agriculture industry44? If so, how could this affect food supply chains and consumer choices? Labour market readiness: Will there be sufficient talent to develop new markets and activities? Where will biodigital talent reside? How will labour markets adapt if digitalization of food production makes certain agricultural jobs obsolete while creating demand for new skills? How readily will education programs for agricultural science and food science incorporate biodigital technologies like vertical farming, AI, robotics, or lab-grown food? Policy considerations The rise of the biodigital convergence could affect many policy areas. The following are not policy recommendations, but rather considerations, questions, and thought-provoking ideas. Food safety regulations and nutrition guidance New types of food production, manufacturing, and supply chains could lead to new packaging, storage, transportation, cooling, handling, preparation, cooking, and sanitizing procedures. Actors could also use blockchain technology to ensure traceability and make the supply chain more transparent. Blockchain could also help consumers access information on ingredients. New categories of plant-based and animal-based foods could emerge from using biodigital production modes and biodata to produce new types of personalized food. This could affect what we consider healthy food, current nutrition guides like the Canada Food Guide, as well as lead to new nutrition facts on labels. International trade, food sovereignty, and supply chains Biodigital food technologies may help countries that heavily rely on food imports to improve their food sovereignty. This could reduce food trade at the global level and have economic impacts on the largest-producing countries of agricultural commodities. The export-import potential of biodigital food products could also lead trade partners to rethink food labeling. Biodigital food production modes could disrupt existing supply chains at the national and global level. Increased local biodigital food production could also reduce the need for food distribution and transportation. The rising digitalization and automation of food production processes and ingredients via emerging biodigital innovations, such as 3D food printers and online platforms, could substantially increase personal and commercial food production capacity. Home biodigital food production could require new safety measures. Countries that have relied on arable land and rural agriculture economies may need to examine the economic sustainability of traditional food production in the face of new food production possibilities. Intellectual property & privacy Digital technologies like AI and big data analysis could increase the number of patents for customized45 flavors46 and recipes47. Secured genomic databanks could become increasingly common. People may be concerned about privacy implications and sharing genome data with food supply chain actors. Global compensation and protection systems may help prevent biodigital food-cloning practices. For example, sequencing appellation48 food goods for local production or growing Kobe beef in a lab. Environmental footprint and spatial development Agricultural land may be stranded and repurposed as we produce more food in vertical farming facilities or through cellular agriculture. Gene-edited crops and smart farming (sensors, robots) could reduce fertilizer, pesticide, and herbicide use. The environmental footprint of emerging biodigital food production and consumption, such as cellular agriculture, gene-edited crops, vertical farming, and smart agriculture may be different from that of the current food system. New innovations may aid climate change goals. However, transitions can be costly and could increase the demand for electricity. Health Biodigital convergence could rapidly advance targeted treatments, and precision medicine based on genomic profiles—leading to improved and targeted preventive care as well as highly efficient treatments for disease. At the same time, biodigital convergence also gives rise to inclusivity and ethical considerations, among others. Healthcare costs are projected to continue increasing over the next 15 years due to factors such as population growth, reproductive problems49, ageing, degenerative diseases, and rising use of expensive, newly patented medicines50. The sector’s labour shortage51 is expected to continue as demand for home care grows, and healthcare worker burnout continues as a result of the COVID-19 pandemic52. On the current trajectory, hospitals and healthcare systems will continue to be overburdened, the scope of public health may grow, and emerging innovations may fall within the scope of health mandates, inflicting more pressure on public health systems. How is biodigital convergence changing health? Technological innovations in the biodigital space will continue to mature and combine. The following section outlines some innovations that could affect the integrated and complex future of human health. Synthetic organs and digital implants. Customized body parts and implants could offer new transplant options. In 2019, over 4000 Canadians53 were on a waiting list for an organ transplant. Human organs can now be 3D-printed54, or grown in genetically modified pigs55. EU regulators approved56 the first totally artificial heart in 2020. Artificial blood vessels57 could help treat cardiovascular disease. Artificial skin, made from stretchable electronics58 that can sense heat and pressure, could improve prosthetics and skin grafts. Such technologies could enable people not only to fix medical problems, but to obtain customized body parts with enhanced capabilities. Brain implants that can be recharged wirelessly59 could transform the treatment of neurological diseases. Implanted chips are already being used to monitor health and unlock smartphones. Implants such as Neuralink60 could expand the human senses, allowing us to “feel”61 bionic limbs, or interact with virtual spaces in new ways. They may also lead to new treatments for mental illnesses like depression62. Brain-computer interfaces allow us to communicate with AI-enabled devices: for example, it can enable blind people to perceive images63 through an artificial eye. These technologies could help repair or enhance the human body. The CRISPRization of humans. As a research tool64, CRISPR gene editing helps us understand DNA’s role in human diseases. Medical researchers are exploring its potential to fight viruses65, destroy cancer66 cells, overcome immune problems that interfere with potential gene therapy67, and treat conditions such as acne68 and blindness69. CRISPR-off technology allows us to turn gene expression off70, effectively stopping a person from getting a disease to which they are genetically predisposed, such as Alzheimer’s. Further, it may be possible to turn off epigenetic markers while leaving the DNA strand intact. CRISPR may increasingly give people the ability to code their own DNA, and that of their children. Some parents may wish to give their children resistance to diseases, enhanced intelligence, and other abilities. Public opinion research71 finds a high level of support for using the technology to prevent rare genetic illnesses in babies, but opposition to using it to improve a baby’s intelligence. Support or rejection of gene editing depends in part on one’s nationality, gender, demographics, religion, and education. Varying levels72 of ethical consideration and debate exist surrounding genetically altering offspring. There are currently widespread international bans on human use of the technology, but the World Health Organization has an advisory committee73 looking at global standards, including oversight and ethical considerations for human genome editing. Tracking human health in real time. The health tech market is actively innovating to find solutions that can support preventative health actions. Wearables that monitor physical health can increasingly track and compile more health data in real time. AI can track moods and mental health74 by analyzing our voices and facial expressions. Researchers are developing DNA testing kits that plug into smartphones75 and could help track disease. Machine learning76 could potentially process data in the cloud that is automatically collected from nano-scale sensors, monitors, and implants in a patient’s body. Increasing knowledge about the human microbiome—the tens of trillions77 of microorganisms that live inside the human body—is leading to more treatments78, research, and lifestyle prescriptions. What might change in healthcare systems in the future? As the biodigital convergence advances and matures, it could reshape health systems in significant ways: Regenerative medicine. We can observe the ability to regrow lost limbs or repair damaged organs in some animals like lizards and amphibians. The same cellular signaling pathways we find in animals capable of regeneration are also present in humans79, and modifications may lead to tissue growth rather than scarring. Stem cell research is also on its way to growing whole organs—starting with smaller organoids80 that can currently perform some function of the larger organs. Biodatabases. DNA databases could become a source of income and health security. In the coming years, it could be possible and relatively simple to collect DNA information using a smartphone. As biodata becomes more ubiquitous, questions surrounding who collects, uses, retains, and discloses it will become pivotal. Applications (apps), smartwatches, and phones are already collecting biodata outside the traditional healthcare sector; an extension of this data collection would be commercial and consumer engagement with biomic or genomic data. DNA data marketplaces81 based on blockchains82 could emerge, allowing individuals—or designated data trusts—to share genomic information with corporations, academic researchers, and even governments in exchange for benefits or payment. DNA databases could provide new insights into the complex links between genes and disease. Genomic data could be a source of power or economic advantage in future economies, as health and healthcare continue to increase in priority. Open biodata or platform-gathering big data from individuals could support the development of new therapies, but may also create privacy83 and accountability risks. Opportunities to collaborate and share data for greater medical efficacy and care could face challenges in individual data protection and trust in the system. Genome data could enable detection84 before the manifestation of disease, furthering long-term preventative cost savings in healthcare systems. The pharmaceutical industry may begin shifting away85 from chemical substances as a source of new drugs, and explore manipulation of living organisms’ DNA as treatment86. DNA databases87 could become a strategic asset and input for the development of new drugs and therapies. Remote healthcare services. Canadians could access more healthcare services remotely. COVID-19 has brought telemedicine and digital health tools into the mainstream, making patients more comfortable using technology to manage their health needs. In the next 10 to 15 years, technological development and the increased proportion of digitally competent people could dramatically accelerate remote healthcare provision. Implanted sensors could monitor individuals’ health around the clock, sending data to the cloud to be analyzed for diagnosis and advice—along with other data, such as from air quality sensors in the workspace, or mental health analysis based on online behaviour. People take control of their evolution. Germline editing—that is, editing genes that can be passed on to the next generation—is currently banned in most jurisdictions88. However, this could change over time as this technology more safely eliminates or improves resilience to diseases, which could improve wellbeing and reduce healthcare costs. In addition, emerging low-cost biodigital devices and services could allow individuals to experience at-home89 germline editing. As a first step, using CRISPR to edit out genetic predispositions to disease could be seen as an extension of the current pre-implantation screening practice in in vitro fertilization. A next step could be to insert preferred physical or psychological traits with high precision, by editing the parent’s germline before conception rather than the embryo. In some countries, governments could seek to incentivize citizens to have healthier babies; over time, this may lead to a cognitive shift, where people consider procreating “naturally” to be reckless. How we want to evolve as a species and what consequences could emerge may become important ethical considerations. Could eugenics90—the process of eliminating undesired genes from a population—re-emerge as a moral dilemma? Healthy choices? Do-it-yourself biology. Biodigital convergence may open up new possibilities, allowing people to choose who they want to be by hacking their own bodies and minds91. The growing availability and affordability of CRISPR kits, online open-source resources, and affordable devices opens up new prospects for DIY bio to treat, alter, or enhance physical or mental capabilities. This could pose a major threat to public health, biosafety, and biosecurity. Unwise or inexpert gene edits could damage experimenters and, if they modify their germline92, their future children. If it becomes possible to select children’s traits and combine DNA inputs from multiple people, traditional motives and selection models for procreation could shift. Recreational implants that activate the pleasure centre of the brain may lead to a new form of addiction. People could choose to shape not only the health but the personality of children, to embody belief systems. When exploring the DIY movement, ethical considerations and the possibilities of procedural errors could lead to unintended consequences93. In the longer term, gene edits that successfully enhance human capabilities could lead to technologies that create a new “superclass” of humans, vastly widening societal and possibly equity divides. Critical uncertainties and future possibilities Various factors could affect the scale and nature of acceptance or rejection of biodigital innovations. The following outlines some possible uncertainties that may lead to different future scenarios. Societal acceptance: Will there be a societal consensus on adopting new technologies? How concerned might people be about the security and privacy implications94 of health data access? To what extent might lab-grown brains95 and other lab-created organisms already be or become conscious? What ethical implications could arise in future health sciences—or even art96—that uses synthetic biology? To what extent might the ability to alter our own genes and brain functions call into question who we are as humans? Business ecosystem: How might existing players change, how could related sectors evolve, and what new players could emerge? To what extent could big tech firms dominate health and healthcare, as Amazon’s logistics and Google’s machine learning capabilities become increasingly important at the research and development (R&D) and healthcare service level? Could individuals monetize their DNA data on an online marketplace? Could DNA marketplaces shift the financial gain of biodata sharing from biodatabase firms to individuals? Economic rollout: How might policies, standards, and ideologies around the world differ, and what consequences or advantages in industry and socioeconomic status could emerge as a result of these differences? Could uneven access to new human augmentation technologies give rise to new forms of economic growth, inequality, and discrimination? Could human augmentation contribute to productivity and be considered a competitive advantage? How would international labour and employment agreements respond to the possible uneven global adoption of human augmentation? Policy considerations The rise of the biodigital convergence could affect many policy areas. The following are not policy recommendations, but rather considerations, questions, and thought-provoking ideas. Role of regulation Augmentation for work, school, or sports situations could give some people unfair advantages. AI outputs from black box machine learning97 could prove problematic in applying AI-based digital therapeutic technologies that can continuously learn and self-modify. It may be difficult to trust the outputs without ensuring a lack of bias in a diagnosis. Networks of biofoundries around the world could reduce the effectiveness of national regulations. Biodata, automation technology, platforms, and cloud-based labs98 could make it easier for organizations to offshore some R&D functions to jurisdictions with or without ethical regulations. Public sector involvement Biodigital innovations that have been developed in response to the COVID-19 pandemic—like health data collection and tracking, and bioproduction, including vaccines, treatments, and supply chains—may be applicable to other public health situations. The multi-sectoral implications of CRISPR treatments may require further discussions about their ethics and possible uses in healthcare. Access to new treatments through public healthcare systems Affordability could affect the speed of new models of healthcare delivery, options, and treatments. Like other digital technologies, biodigital technologies may require ongoing and regular software support to maintain their effectiveness. Governments may be required to step in if private sector suppliers withdraw their support99. Equitable healthcare access for remote areas Telemedicine, remote biosensing, and local bioproduction could offer different possibilities for diagnosis and treatment. In Canada, these medical services may benefit remote or rural areas. Remote collection of biodata in areas with limited access to reliable Internet may be a challenge to universal accessibility. R&D, data sharing, and privacy International agreements and collaboration on the future of health data could result in alliances and disputes. Open-source science100 may challenge existing intellectual property frameworks related to diagnostics, therapies, treatments, and manufacturing. The value of biodata may increase with the growing use of AI in drug discovery that relies on that data to generate products. There may be international implementation of agreements, such as access and benefit-sharing systems101 under the Convention on Biological Diversity102 for example, that affect access to genetic resources from biodiversity that may be used for new drugs and therapeutics. The digital nature of people’s biodata, and the ability to easily transfer or access it via online platforms could drive discussions about biodata sharing, storage, access, and privacy. Environment Climate change, pollution, and biodiversity loss are widely recognized as urgent global issues. Today’s unsustainable production and consumption modes are endangering long-term socioeconomic wellbeing. Biodigital capabilities could increase our capacity to connect with and monitor the natural world. It could also expand our understanding of the interconnectedness of all living things. Genetic modification of the natural world for climate change mitigation, environmental remediation, and biodiversity conservation may however raise ethical considerations. Furthermore, there may be unintended consequences involved with the release of modified organisms in natural environments. Few countries are on course to reach their carbon emission reduction targets. The cost of extreme weather events103 caused by climate change104—such as fires, droughts, floods, and hurricanes—may continue to rise. Other environmental crises may also intensify, from plastic pollution to biodiversity loss, to pollution of air, soil, and water. Despite a trend towards voluntary corporate disclosures105 and private sector investment against climate change, public policy remains key to environmental protection. How is biodigital convergence changing the environment? Biodigital innovations will continue to mature and combine. The following section outlines some innovations that could affect the future of ecosystems, biodiversity, and climate change. Hybrid biodiversity. People may augment natural ecosystems and biodiversity to increase resilience. Gene editing106 is enabling the creation of new forms of biodiversity, from plants that glow in the dark107 to nanobionic sensors that monitor arsenic levels108 in soil. Researchers are using CRISPR gene editing for projects such as improving the resilience of forest ecosystems109, and bringing the woolly mammoth110 back from extinction. Gene drives111 allow people to introduce certain genetic traits into an animal or insect population. This could help control invasive species112, restore coral reefs113, or prevent insect-borne diseases. For example, Florida released 750 million genetically engineered mosquitoes114 as an alternative to using insecticide. These interventions are not without risk, as it may be difficult to stop their spread once modified genes are released into nature. Environmental clean-ups through synthetic biology. Scientists are developing jellyfish115 that can detoxify contaminated ocean; bacteria- and yeast116-based smart materials that can sense environmental contaminants; and microbes that can destroy117 pollutants in soil and water, recover rare earth metals118 from polluted land, and clean up oil spills119. Carbon dioxide can be extracted from the atmosphere by genetically engineered weeds120 and fast-growing algae121, cultivated into biomass in specially designed bioreactors, and then harvested as fuel, fertilizers, oils, and plastics. Internet of Living Things. Although in its early stages, it is possible to discern the beginnings of an “Internet of Living Things” (IoLT) similar to the current Internet of Things (IoT). Plants’ sensitivity to chemicals, combined with technology, opens up new capabilities. For instance, spinach can send an email to warn about landmines122. If its roots detect a specific explosive chemical, the plant emits a signal that is picked up by a sensor, triggering an email to researchers. CRISPR has been used to edit genes to store binary information—the kind used in computers—in DNA form, allowing researchers to encode the phrase “hello world” into an E. coli cell123. Microsoft is exploring the future potential to store data124 in biochemical systems; theoretically, a gram of DNA could hold 215,000 terabytes125 of data, which people could read using portable DNA sequencers126. What might change in the environment in the future? As the biodigital convergence advances and matures, it could reshape the environment, biodiversity, and ecosystems in significant ways: Modifying the environment. Biodigital interventions could increase the value of ecosystem services. The value of ecosystem services127—the benefits we gain from a functioning natural environment, from clean water to flood protection—has an estimated worth of 1.5 times more than the global GDP. Artificial biodiversity could add even more value, from microorganisms that break down plastic pollutants128 and oil129, to glow-in-the-dark trees130 that replace street lights, to soils that absorb more water131 to mitigate flooding, and trees that are more resistant to forest fires. Technologically enhanced biodiversity could transform ecosystems that are currently uninhabitable to humans, and provide alternatives to geoengineering132 for tackling climate change. Environmental biosensors and data collection. Better data could transform environmental monitoring and governance. Environmental protection laws have historically legalized environmental harms from human activity by setting pollution emission caps. Genetically modified plants could monitor anti-pollution laws, detecting pollutants and triggering alerts to the relevant authorities. Biodigital sensors, drones, robotics, and sequencing of DNA fragments in the environment133 could help monitor air, water, and soil quality more widely and in greater detail, including at remote extraction sites. Releasing smart biodigital living entities into ecosystems could share real-time signals with authorities, identifying harmful substances, microbes, or pollutants. This could potentially replace or support pollution emission standards and lead to personalized, real-time environmental legislation. Additionally, emerging fields of study like imageomics134—where machine learning is used to extract biological traits from wildlife images of living organisms captured by drones or uploaded on platforms such as eBird135 and iNaturalist136—could rapidly improve our understanding of biological processes and detect early signs of harm to biodiversity. Environmental DNA137 (eDNA) can identify species in an area without directly observing them. This could allow for better understanding of the environmental impacts of proposed projects and policies138, as well as environmental monitoring139 of ongoing human activities. It could also lead to new ways of determining the economic value of living things, illustrating the value of ecosystem services. Moreover, it could help track how species140 move in response to climate change and facilitate early detection of invasive species. Collecting eDNA in seafood markets may improve wildlife crime investigation141 techniques by detecting the sale of endangered and protected fish species. The emergence of eDNA might call for reflections on who controls that data and what uses are ethical. Deeper green Redefining the concepts of natural and artificial. That nature exists and evolves more as an art than a science is a prevailing assumption. However, our understanding of the mechanisms that govern life has reached a point where we can modify biological instructions, to program organisms to perform specific tasks. There are signs of a cognitive shift142 in which society increasingly values biological entities. There is an emerging philosophy, based on new development of living robots143, that organisms act as “hardware,” and DNA and cellular communication (via electric gradients144) are the “software” that dictates the hardware’s function. The ability to reshape ecosystems by eliminating or reviving145 certain species, or directing how they evolve, raises ethical146 questions about the rights of species and ecosystems, and the risk of unintended consequences if our ability to reshape ecosystems outpaces our capacity to understand them. As people are still trying to map and understand the intricacies of ecosystems, our understanding may be limited and ever-evolving, even with the help of technology. There may be a risk of harming nature when influencing or manipulating the intricacies of the natural world. Indigenous perspectives could offer deeper insight into and awareness of the potential ramifications of new biotechnologies. Acknowledging and thinking about implications seven generations into the future, as many traditional Indigenous teachings suggest, could guide ethical considerations of biodigital innovations. Critical uncertainties and future possibilities Various factors could affect the scale and nature of acceptance or rejection of biodigital innovations. The following outlines some possible uncertainties that may lead to different future scenarios. Societal acceptance: Will there be a societal consensus on adopting new technologies? As the next generation of children grows up familiar with digital and biological technologies, will public consciousness shift towards a realization that humans are an integral part of larger ecological systems? Could there be a wider recognition of the importance of safeguarding ecosystems for their socioeconomic value? Might there be backlash to greater modification of the environment? By whom, and what form could it take? If it becomes feasible147 to store data cost-effectively in the DNA of living organisms, could some plants play a new market-based role in the digital economy? Would we want to establish new forms of sensing and connecting with nature? If portable sequencers become accessible and cheap, would people use them to assess the state of biodiversity or discover new pathogens? Environmental ecosystem: How might the environment be affected and how might it react? Should the precautionary principle be applied? How great are the risks of unforeseen consequences? For example, new artificial microorganisms could disrupt the food chain, create new forms of pollution, cause new allergies, or themselves become a form of waste. Policy considerations The rise of the biodigital convergence could affect many policy areas. The following are not policy recommendations, but rather considerations, questions, and thought-provoking ideas. Economic development Environmental sequencing could reveal causality between economic activities and their impacts on biodiversity and ecosystems. Land could become a key tool for companies to mitigate their environmental footprint with artificial biodiversity, using it to compensate for the environmental impacts of economic activity. An IoLT system could be deployed at large scale and be dominated, like the Internet, by a small number of powerful companies. Intellectual property Current intellectual property rights may have to shift to encompass entities in nature, raising questions about whether to consider new organisms a private or a public good. With better sequencing technologies available, governments may have to clarify at the international level rules regarding the access, ownership, and benefit sharing of digital sequence information148, and its legal status149 under the Convention on Biological Diversity. Environmental regulation & enforcement New regulatory frameworks at various levels may affect the introduction of new genetically modified organisms. Rules on reproduction of new modified species could vary. Migration of genetically modified species could be difficult to control across jurisdictional borders. Emerging digital and biosensors could act as tools to monitor environmental quality and biodiversity loss. Creating communication channels with the help of digital technologies between living organisms and regulators could facilitate rule enforcement. Security Emerging biodigital innovations and capabilities are creating both new frontiers and possible concerns in the field of security and defence. With almost five billion people connected to the Internet, digital surveillance and data collection have substantially increased over the last decade. The rise of biodata may add a new layer of complexity in securing potentially valuable personal data. The access to more data may also facilitate criminal investigation and potentially create a more secure society. The IoT is being deployed around the world in smart cities, which allow authorities and private actors to monitor citizen movements. These technologies have led to privacy issues and much controversy150. Combined with the rapidly declining cost of DNA sequencing, a large amount of biodata could be generated over the next decade, facilitating biosurveillance in the future. Moreover, the rise of DIY bio-capabilities and the access to emerging biotechnologies could facilitate new forms of biowarfare and bioterrorism. How is biodigital convergence changing security? Biodigital innovations will continue to mature and combine. The following section outlines some innovations that could affect the future of security. The rise of biodatabases. The adoption of biodatabases and DNA biodata by private or public entities may have privacy and national defence risks. Because of its nature and the type of information it contains, biodata could lead to new tiers of threat. Consent, access, and nefarious use could pose severe risks for individuals, and for security and defence operations to manage. The cost of gene sequencing is rapidly declining: in 2020, a Chinese firm claimed it could sequence a full genome for $100151. Some governments have established DNA databases: the U.S. has accumulated around 14 million152 samples on criminal suspects, with an overrepresentation of black men; and China routinely153 collects DNA from male citizens for predictive policing. Researchers are working on using DNA to predict154 how a person’s face will look, so DNA databases can inform surveillance through facial recognition software. Many people voluntarily give their DNA in exchange for information on their health or ancestry, or to support medical research, such as the FinnGen study155. While some human genetic-testing companies have comprehensive156 privacy policies, many others do not157. Some judges have ordered158 companies to share customers’ DNA with law enforcement agencies, and nearly half of Americans support police access to private DNA databases. Biodatabases can be a useful tool for forensics. Cold cases over a decade old may be reopened159 as DNA data is more abundant and easier to access. Theoretically, bad actors may be able to hack160 into and identify individuals in open-source databases161, to which people upload their DNA in search of relatives or medical studies. International entities trade surveillance technology abroad without similar regulations as arms dealing, even though many consider the impacts of technology to pose similar dangers. Many are calling for DNA databases and facial recognition technology to be classified as weapons162 in an attempt to regulate this global trade and monitor their use by authoritarian regimes. The race between biothreats and biodefence. Much like the Internet, biodigital convergence is seeing a new and continuing struggle between attack and defence. The U.S. has classified gene editing as a potential weapon of mass destruction163 and the FBI has a biocrime department. New technologies can indicate when a person is becoming ill164, and enable early detection165 of which virus or bacteria they may have. The U.S. Army is looking at wearable166 biosensors for soldiers to detect biothreats. While it can be difficult to differentiate natural from artificially engineered pathogens, the technology is improving167. It is increasingly feasible for individuals to sequence and synthesize DNA, with DIY gene-editing kits retailing online168 for as little as US$169. Aims of the DIY bio movement include making insulin and other medicines more affordable169. However, DIY bio also increases the risk of either deliberately or accidentally releasing DIY pathogens170. California has become the first U.S. state to pass a law171 specifically to restrict the use of CRISPR, but regulations differ from place to place. What might change in security in the future? As the biodigital convergence advances and matures, it could reshape security and defence systems in significant ways: Modern biothreats. Weaponization of biotechnology could lead to a rise in threats to society. While only organizations with significant resources and expertise can hope to develop a nuclear weapon, it may be increasingly feasible for individuals or small groups to develop potentially devastating bioweapons, such as a version of the Ebola virus modified to spread more easily. It is harder to anticipate the potential for scale and collateral damage of new bioweapons compared to more traditional weapons. Adverse actors with a long-term agenda could invest in or infiltrate start-ups in the biotech field, while cyberattacks on biological research institutes172 could allow access to knowledge that can be weaponized using readily available technologies and materials. Vaccine researchers, for example, routinely create synthetic viruses to test strategies. The recent reproduction of the extinct horsepox virus173 raised concerns that smallpox could be synthesized and weaponized. Similarly, research into neurotoxins such as tetrodotoxin174—produced by pufferfish—could inform the development of bioweapons. Terrorist groups and rogue nations could also target a nation’s food supply with bioweapons: agroterrorism175 could involve pathogens that affect cultivated crops or forests176. The rise of biosurveillance. Biological threats require new ways of thinking about monitoring and border control. With a significant increase in international trade, we may need to implement intelligent biodetection systems to monitor and give timely warnings about new viruses, bacteria, or other genetically engineered pathogens. New biosensing technology could be deployed at borders in an attempt to protect them against biological threats. Synthetic biology techniques and raw materials are dual-use, raising questions about regulation of international trade in resources such as yeast cultures and algae strains. Raw biomaterials may need new types of border oversight and tracking, as their end products could vary. Biological threats may impact national defence priorities, as nations pivot to create biopreparedness. However, biothreats cross many policy domains, including environment, health, national security, and border control. Identity crises The ethics of DNA sequencing. Genomic data could have far-reaching consequences for economic competitiveness, and questions of identity, equity, and discrimination. It is becoming financially feasible for businesses to create DNA databases of their customers and enable business models in which consumers trade their DNA data for free services. Firms currently track digital data to create consumer or even electoral profiles177. Tracking biodata profiles could be an extension of this. With advances in genomic analytics, firms could access a bioprofile of who you are178 and gain a broader understanding of your identity. Moreover, genomic data could become a new form of digital authentication. Security and surveillance could bleed into equity practices and ethical domains. Sharing individuals’ genetic identity could create new challenges to equity, if access to education or employment opportunities depended on whether DNA tests suggest suitability for a given career. Similarly, access to healthcare, insurance, or immigration opportunities could depend on DNA tests for susceptibility to expensive-to-treat diseases. Ethno-nationalist movements could discriminate based on DNA or create communities rooted in shared ancestry, leading to geopolitical divergence, social unrest, or new types of inequity and discrimination. As an individual’s DNA gains importance, a black market in fake DNA evidence179 could emerge. People could avoid tracking by using CRISPR technologies to alter their DNA. More institutions may use biodata as a means of authorization, which could open up a new avenue for identity theft. Critical uncertainties and future possibilities Various factors could affect the scale and nature of acceptance or rejection of biodigital innovations. The following outlines some possible uncertainties that may lead to different future scenarios. Societal acceptance: Will there be a societal consensus on adopting new technologies and supporting this industry? Could their potential for use in bioweapons sway the public against potentially beneficial uses of synthetic biology and gene-editing technologies? Could attitudes towards justice and predictive policing180 change if it becomes possible to use genetic profiling181 to predict future criminal behaviour with a high degree of confidence from an individual’s DNA? Might concerns about biohazards lead more people to move to isolated areas or seek to make their properties more biosecure182? How might differing cultural attitudes183 shape responses to biothreats in different countries? Business ecosystem: What might be the shape of businesses in this space, how might related sectors evolve, what new players could emerge, and how might they evolve over time? Might the nature of biothreats require international standards184, or will countries develop their own parameters and regulations on capturing, storing, and sharing biodata? Could large companies monopolize synthetic biology, since smaller entities may not have the resources to meet the biosafety requirements for high-risk activities? How might firms, organizations, and governments reach an appropriate balance between innovation and regulations, bans185, and moratoriums? How would bioinnovation organizations address a higher risk of industrial espionage186 and cyber attacks187? Labour market readiness: Will there be sufficient talent188 to develop new markets and activities? Where will biodigital talent reside? Could we see national defence departments and security firms employ a growing number of “bio” experts? Economic rollout: How can policies adapt and stay ahead of transitions? What new protocols and regulations are needed to securely trade biodata? What safety standards and regulations, such as government-issued licenses, might be required to conduct DIY biology? Policy considerations The rise of the biodigital convergence could affect many policy areas. The following are not policy recommendations, but rather considerations, questions, and thought-provoking ideas. Biosecurity and biothreats Nefarious actors could learn from failures to detect, mitigate, and respond to the COVID-19 pandemic189, and the underlying socioeconomic impacts, increasing the likelihood of future biological weapon attacks. The digital components of wearable or implanted devices could be hacked, leading to biological harm to the user. Open-source science and international sharing of research data could lead to international surveillance and authentication. Biodigital convergence could enable individuals to develop low-cost biothreats. Some countries might create, redesign, and invest in new infrastructure to prevent or mitigate potential biothreats. National security Disinformation and fake news about emerging biodigital technologies could contribute to changing social attitudes, behaviour, and subsequently become a national security concern. With the rise of low-cost DIY biolabs and easier access to technologies like DNA synthesis, front-line emergency services such as policing, firefighters, and paramedics might need training to detect labs, biohazardous organisms, and potentially human augmentation. There may be a rise in human augmentation, which could lead some countries to develop augmentation detection capabilities and regulations. Military and defence Defence departments might consider national and global defensive and offensive solutions to potential biothreats, similar to past nuclear and anti-missile defence programs. Manufacturing Manufacturing was historically based on factory workers who transformed natural resources initially extracted from mines, forests, and waters, or grown on farms. Differences in labour costs and the natural distribution of resources have influenced the shape of our far-reaching global supply chains. Biodigital convergence could transform the natural resource sector through new ways of making and obtaining raw materials and fuels, as well as new manufacturing techniques, potentially easing pressure on natural resources. More localized production and distribution of goods and fuels